Radiation-induced dedifferentiated chondrosarcoma with orbital invasion

Brett W. Davies; Christina R. Prescott; Sherif A. Said; John Campana; Flávia A. Attié-Castro; Antonio Augusto Velasco E Cruz; Vikram D. Durairaj

doi:10.1097/IOP.0000000000000168

Radiation-induced dedifferentiated chondrosarcoma with orbital invasion

Brett W. Davies, Christina R. Prescott, Sherif A. Said, John Campana, Flávia A. Attié-Castro, Antonio Augusto Velasco E Cruz, Vikram D. Durairaj

School of Medicine

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

PURPOSE: To report 2 interventional cases of dedifferentiated chondrosarcoma with orbital involvement after radiotherapy performed in childhood and to review the literature on chondrosarcoma in the orbit following radiation treatment. METHODS: Retrospective analysis of medical records of 2 patients with chondrosarcoma of the orbits with review of the literature. RESULTS: The first patient developed chondrosarcoma of the orbital and maxillary sinus 36 years after external beam radiation therapy to the OS to treat retinoblastoma. The second patient developed a large orbital chondrosarcoma 35 years after external beam radiation therapy in the treatment of craniofacial fibrous dysplasia. CONCLUSIONS: These cases highlight the risk of secondary chondrosarcoma in patients following radiotherapy and the importance of lifetime monitoring.

Original language	English (US)
Pages (from-to)	205-208
Number of pages	4
Journal	Ophthalmic plastic and reconstructive surgery
Volume	30
Issue number	3
DOIs	https://doi.org/10.1097/IOP.0000000000000168
State	Published - 2014

ASJC Scopus subject areas

Surgery
Ophthalmology

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10.1097/IOP.0000000000000168

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title = "Radiation-induced dedifferentiated chondrosarcoma with orbital invasion",

abstract = "PURPOSE: To report 2 interventional cases of dedifferentiated chondrosarcoma with orbital involvement after radiotherapy performed in childhood and to review the literature on chondrosarcoma in the orbit following radiation treatment. METHODS: Retrospective analysis of medical records of 2 patients with chondrosarcoma of the orbits with review of the literature. RESULTS: The first patient developed chondrosarcoma of the orbital and maxillary sinus 36 years after external beam radiation therapy to the OS to treat retinoblastoma. The second patient developed a large orbital chondrosarcoma 35 years after external beam radiation therapy in the treatment of craniofacial fibrous dysplasia. CONCLUSIONS: These cases highlight the risk of secondary chondrosarcoma in patients following radiotherapy and the importance of lifetime monitoring.",

author = "Davies, {Brett W.} and Prescott, {Christina R.} and Said, {Sherif A.} and John Campana and Atti{\'e}-Castro, {Fl{\'a}via A.} and {Velasco E Cruz}, {Antonio Augusto} and Durairaj, {Vikram D.}",

year = "2014",

doi = "10.1097/IOP.0000000000000168",

language = "English (US)",

volume = "30",

pages = "205--208",

journal = "Ophthalmic plastic and reconstructive surgery",

issn = "0740-9303",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Radiation-induced dedifferentiated chondrosarcoma with orbital invasion

AU - Davies, Brett W.

AU - Prescott, Christina R.

AU - Said, Sherif A.

AU - Campana, John

AU - Attié-Castro, Flávia A.

AU - Velasco E Cruz, Antonio Augusto

AU - Durairaj, Vikram D.

PY - 2014

Y1 - 2014

N2 - PURPOSE: To report 2 interventional cases of dedifferentiated chondrosarcoma with orbital involvement after radiotherapy performed in childhood and to review the literature on chondrosarcoma in the orbit following radiation treatment. METHODS: Retrospective analysis of medical records of 2 patients with chondrosarcoma of the orbits with review of the literature. RESULTS: The first patient developed chondrosarcoma of the orbital and maxillary sinus 36 years after external beam radiation therapy to the OS to treat retinoblastoma. The second patient developed a large orbital chondrosarcoma 35 years after external beam radiation therapy in the treatment of craniofacial fibrous dysplasia. CONCLUSIONS: These cases highlight the risk of secondary chondrosarcoma in patients following radiotherapy and the importance of lifetime monitoring.

AB - PURPOSE: To report 2 interventional cases of dedifferentiated chondrosarcoma with orbital involvement after radiotherapy performed in childhood and to review the literature on chondrosarcoma in the orbit following radiation treatment. METHODS: Retrospective analysis of medical records of 2 patients with chondrosarcoma of the orbits with review of the literature. RESULTS: The first patient developed chondrosarcoma of the orbital and maxillary sinus 36 years after external beam radiation therapy to the OS to treat retinoblastoma. The second patient developed a large orbital chondrosarcoma 35 years after external beam radiation therapy in the treatment of craniofacial fibrous dysplasia. CONCLUSIONS: These cases highlight the risk of secondary chondrosarcoma in patients following radiotherapy and the importance of lifetime monitoring.

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AN - SCOPUS:84900563790

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JO - Ophthalmic plastic and reconstructive surgery

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Radiation-induced dedifferentiated chondrosarcoma with orbital invasion

Abstract

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