Radiation-induced dedifferentiated chondrosarcoma with orbital invasion

Brett W. Davies, Christina R. Prescott, Sherif A. Said, John Campana, Flávia A. Attié-Castro, Antonio Augusto Velasco E Cruz, Vikram D. Durairaj

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


PURPOSE: To report 2 interventional cases of dedifferentiated chondrosarcoma with orbital involvement after radiotherapy performed in childhood and to review the literature on chondrosarcoma in the orbit following radiation treatment. METHODS: Retrospective analysis of medical records of 2 patients with chondrosarcoma of the orbits with review of the literature. RESULTS: The first patient developed chondrosarcoma of the orbital and maxillary sinus 36 years after external beam radiation therapy to the OS to treat retinoblastoma. The second patient developed a large orbital chondrosarcoma 35 years after external beam radiation therapy in the treatment of craniofacial fibrous dysplasia. CONCLUSIONS: These cases highlight the risk of secondary chondrosarcoma in patients following radiotherapy and the importance of lifetime monitoring.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalOphthalmic plastic and reconstructive surgery
Issue number3
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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