Radiation-Associated Sarcoma of the Neck: Case Series and Systematic Review

Lawrence Williams, Lyubov Tmanova, Wojciech Mydlarz, Brandi Page, Jeremy D. Richmon, Harry Quon, Nicole Schmitt

Research output: Contribution to journalArticle

Abstract

Introduction: Radiation-associated soft tissue sarcomas of the neck (RASN) constitute a rare and aggressive tumor type. Methods: A retrospective chart review at the authors’ institution revealed 3 patients with RASN. A systematic review of the literature was also conducted using MEDLINE, Ovid, the Cochrane Library, and Embase. Results: Patients within the authors’ institutional chart review presented from 6 to 26 years after neck radiation with neck masses. All patients underwent surgical resection with clear margins, and adjuvant radiation was offered when feasible. Patients had no evidence of disease at most recent follow-up. A total of 867 articles were screened for systematic review, revealing 9 articles detailing outcomes of RASN. Studies were small and heterogeneous, precluding pooled data. The importance of complete surgical extirpation was noted. Conclusions: Complete surgical resection appears to be the mainstay of therapy, but there are limited data on management and outcomes of patients with RASN.

Original languageEnglish (US)
JournalAnnals of Otology, Rhinology and Laryngology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Sarcoma
Neck
Radiation
MEDLINE
Libraries
Neoplasms

Keywords

  • head and neck sarcoma
  • pleomorphic sarcoma
  • radiation
  • radiation-induced sarcoma
  • soft tissue sarcoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Radiation-Associated Sarcoma of the Neck : Case Series and Systematic Review. / Williams, Lawrence; Tmanova, Lyubov; Mydlarz, Wojciech; Page, Brandi; Richmon, Jeremy D.; Quon, Harry; Schmitt, Nicole.

In: Annals of Otology, Rhinology and Laryngology, 01.01.2018.

Research output: Contribution to journalArticle

@article{fb940ed1908141b2aa22844e257364d5,
title = "Radiation-Associated Sarcoma of the Neck: Case Series and Systematic Review",
abstract = "Introduction: Radiation-associated soft tissue sarcomas of the neck (RASN) constitute a rare and aggressive tumor type. Methods: A retrospective chart review at the authors’ institution revealed 3 patients with RASN. A systematic review of the literature was also conducted using MEDLINE, Ovid, the Cochrane Library, and Embase. Results: Patients within the authors’ institutional chart review presented from 6 to 26 years after neck radiation with neck masses. All patients underwent surgical resection with clear margins, and adjuvant radiation was offered when feasible. Patients had no evidence of disease at most recent follow-up. A total of 867 articles were screened for systematic review, revealing 9 articles detailing outcomes of RASN. Studies were small and heterogeneous, precluding pooled data. The importance of complete surgical extirpation was noted. Conclusions: Complete surgical resection appears to be the mainstay of therapy, but there are limited data on management and outcomes of patients with RASN.",
keywords = "head and neck sarcoma, pleomorphic sarcoma, radiation, radiation-induced sarcoma, soft tissue sarcoma",
author = "Lawrence Williams and Lyubov Tmanova and Wojciech Mydlarz and Brandi Page and Richmon, {Jeremy D.} and Harry Quon and Nicole Schmitt",
year = "2018",
month = "1",
day = "1",
doi = "10.1177/0003489418789966",
language = "English (US)",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",

}

TY - JOUR

T1 - Radiation-Associated Sarcoma of the Neck

T2 - Case Series and Systematic Review

AU - Williams, Lawrence

AU - Tmanova, Lyubov

AU - Mydlarz, Wojciech

AU - Page, Brandi

AU - Richmon, Jeremy D.

AU - Quon, Harry

AU - Schmitt, Nicole

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: Radiation-associated soft tissue sarcomas of the neck (RASN) constitute a rare and aggressive tumor type. Methods: A retrospective chart review at the authors’ institution revealed 3 patients with RASN. A systematic review of the literature was also conducted using MEDLINE, Ovid, the Cochrane Library, and Embase. Results: Patients within the authors’ institutional chart review presented from 6 to 26 years after neck radiation with neck masses. All patients underwent surgical resection with clear margins, and adjuvant radiation was offered when feasible. Patients had no evidence of disease at most recent follow-up. A total of 867 articles were screened for systematic review, revealing 9 articles detailing outcomes of RASN. Studies were small and heterogeneous, precluding pooled data. The importance of complete surgical extirpation was noted. Conclusions: Complete surgical resection appears to be the mainstay of therapy, but there are limited data on management and outcomes of patients with RASN.

AB - Introduction: Radiation-associated soft tissue sarcomas of the neck (RASN) constitute a rare and aggressive tumor type. Methods: A retrospective chart review at the authors’ institution revealed 3 patients with RASN. A systematic review of the literature was also conducted using MEDLINE, Ovid, the Cochrane Library, and Embase. Results: Patients within the authors’ institutional chart review presented from 6 to 26 years after neck radiation with neck masses. All patients underwent surgical resection with clear margins, and adjuvant radiation was offered when feasible. Patients had no evidence of disease at most recent follow-up. A total of 867 articles were screened for systematic review, revealing 9 articles detailing outcomes of RASN. Studies were small and heterogeneous, precluding pooled data. The importance of complete surgical extirpation was noted. Conclusions: Complete surgical resection appears to be the mainstay of therapy, but there are limited data on management and outcomes of patients with RASN.

KW - head and neck sarcoma

KW - pleomorphic sarcoma

KW - radiation

KW - radiation-induced sarcoma

KW - soft tissue sarcoma

UR - http://www.scopus.com/inward/record.url?scp=85052239033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052239033&partnerID=8YFLogxK

U2 - 10.1177/0003489418789966

DO - 10.1177/0003489418789966

M3 - Article

C2 - 30047787

AN - SCOPUS:85052239033

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

ER -