Radiation and chemotherapy

H. A. Pitt, A. Nakeeb

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cholangiocarcinoma is an uncommon tumor that may occur anywhere along the intrahepatic or extrahepatic biliary tree. In the United States approximately 5,000 cholangiocarcinomas are diagnosed per year while many more biliary malignancies occur in Asia. The hepatic duct bifurcation is the most frequently involved site, and approximately 50-70 % of cholangiocarcinomas are found in this perihilar region [1]. The role of radiation therapy, chemoradiation and chemotherapy as adjuvants to surgical resection in patients with perihilar cholangiocarcinoma remains controversial. Aggressive surgical resection obtaining a negative microscopic margin offers the only chance for long-term survival. However, many patients will only be candidates for nonoperative stenting or palliative surgery aimed to provide biliary drainage and prevent cholangitis and hepatic failure. Radiation therapy, chemoradiation and/or chemotherapy also can be used in these patients with nonresectable disease in an attempt to palliate symptoms and extend survival.

Original languageEnglish (US)
Title of host publicationHilar Cholangiocarcinoma
PublisherSpringer Netherlands
Pages317-322
Number of pages6
ISBN (Print)9789400764736, 9400764723, 9789400764729
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Cholangiocarcinoma
Radiation
Drug Therapy
Klatskin Tumor
Radiotherapy
Common Hepatic Duct
Cholangitis
Survival
Liver Failure
Biliary Tract
Adjuvant Chemotherapy
Palliative Care
Drainage
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pitt, H. A., & Nakeeb, A. (2013). Radiation and chemotherapy. In Hilar Cholangiocarcinoma (pp. 317-322). Springer Netherlands. https://doi.org/10.1007/978-94-007-6473-6_31

Radiation and chemotherapy. / Pitt, H. A.; Nakeeb, A.

Hilar Cholangiocarcinoma. Springer Netherlands, 2013. p. 317-322.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pitt, HA & Nakeeb, A 2013, Radiation and chemotherapy. in Hilar Cholangiocarcinoma. Springer Netherlands, pp. 317-322. https://doi.org/10.1007/978-94-007-6473-6_31
Pitt HA, Nakeeb A. Radiation and chemotherapy. In Hilar Cholangiocarcinoma. Springer Netherlands. 2013. p. 317-322 https://doi.org/10.1007/978-94-007-6473-6_31
Pitt, H. A. ; Nakeeb, A. / Radiation and chemotherapy. Hilar Cholangiocarcinoma. Springer Netherlands, 2013. pp. 317-322
@inbook{2b471bd9cec64c8db34b9a23d078dc94,
title = "Radiation and chemotherapy",
abstract = "Cholangiocarcinoma is an uncommon tumor that may occur anywhere along the intrahepatic or extrahepatic biliary tree. In the United States approximately 5,000 cholangiocarcinomas are diagnosed per year while many more biliary malignancies occur in Asia. The hepatic duct bifurcation is the most frequently involved site, and approximately 50-70 {\%} of cholangiocarcinomas are found in this perihilar region [1]. The role of radiation therapy, chemoradiation and chemotherapy as adjuvants to surgical resection in patients with perihilar cholangiocarcinoma remains controversial. Aggressive surgical resection obtaining a negative microscopic margin offers the only chance for long-term survival. However, many patients will only be candidates for nonoperative stenting or palliative surgery aimed to provide biliary drainage and prevent cholangitis and hepatic failure. Radiation therapy, chemoradiation and/or chemotherapy also can be used in these patients with nonresectable disease in an attempt to palliate symptoms and extend survival.",
author = "Pitt, {H. A.} and A. Nakeeb",
year = "2013",
month = "1",
day = "1",
doi = "10.1007/978-94-007-6473-6_31",
language = "English (US)",
isbn = "9789400764736",
pages = "317--322",
booktitle = "Hilar Cholangiocarcinoma",
publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Radiation and chemotherapy

AU - Pitt, H. A.

AU - Nakeeb, A.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Cholangiocarcinoma is an uncommon tumor that may occur anywhere along the intrahepatic or extrahepatic biliary tree. In the United States approximately 5,000 cholangiocarcinomas are diagnosed per year while many more biliary malignancies occur in Asia. The hepatic duct bifurcation is the most frequently involved site, and approximately 50-70 % of cholangiocarcinomas are found in this perihilar region [1]. The role of radiation therapy, chemoradiation and chemotherapy as adjuvants to surgical resection in patients with perihilar cholangiocarcinoma remains controversial. Aggressive surgical resection obtaining a negative microscopic margin offers the only chance for long-term survival. However, many patients will only be candidates for nonoperative stenting or palliative surgery aimed to provide biliary drainage and prevent cholangitis and hepatic failure. Radiation therapy, chemoradiation and/or chemotherapy also can be used in these patients with nonresectable disease in an attempt to palliate symptoms and extend survival.

AB - Cholangiocarcinoma is an uncommon tumor that may occur anywhere along the intrahepatic or extrahepatic biliary tree. In the United States approximately 5,000 cholangiocarcinomas are diagnosed per year while many more biliary malignancies occur in Asia. The hepatic duct bifurcation is the most frequently involved site, and approximately 50-70 % of cholangiocarcinomas are found in this perihilar region [1]. The role of radiation therapy, chemoradiation and chemotherapy as adjuvants to surgical resection in patients with perihilar cholangiocarcinoma remains controversial. Aggressive surgical resection obtaining a negative microscopic margin offers the only chance for long-term survival. However, many patients will only be candidates for nonoperative stenting or palliative surgery aimed to provide biliary drainage and prevent cholangitis and hepatic failure. Radiation therapy, chemoradiation and/or chemotherapy also can be used in these patients with nonresectable disease in an attempt to palliate symptoms and extend survival.

UR - http://www.scopus.com/inward/record.url?scp=84931434579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931434579&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-6473-6_31

DO - 10.1007/978-94-007-6473-6_31

M3 - Chapter

AN - SCOPUS:84931434579

SN - 9789400764736

SN - 9400764723

SN - 9789400764729

SP - 317

EP - 322

BT - Hilar Cholangiocarcinoma

PB - Springer Netherlands

ER -