Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

Myrna G. Serrano, Hardik I. Parikh, J. Paul Brooks, David J. Edwards, Tom J. Arodz, Laahirie Edupuganti, Bernice Huang, Philippe H. Girerd, Yahya A. Bokhari, Steven P. Bradley, Jamie L. Brooks, Molly R. Dickinson, Jennifer I. Drake, Robert A. Duckworth, Stephen S. Fong, Abigail L. Glascock, Sophonie Jean, Nicole R. Jimenez, Joseph Khoury, Vishal N. Koparde & 21 others Ana M. Lara, Vladimir Lee, Andrey V. Matveyev, Sarah H. Milton, Shreni D. Mistry, Sarah K. Rozycki, Nihar U. Sheth, Ekaterina Smirnova, Stephany C. Vivadelli, N. Romesh Wijesooriya, Jie Xu, Ping Xu, Donald O. Chaffin, Amber L. Sexton, Michael G. Gravett, Craig E. Rubens, Karen D. Hendricks-Muñoz, Kimberly K. Jefferson, Jerome F. Strauss, Jennifer M. Fettweis, Gregory A. Buck

Research output: Contribution to journalArticle

Abstract

The microbiome of the female reproductive tract has implications for women’s reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.

Original languageEnglish (US)
JournalNature medicine
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Microbiota
Pregnancy
Hispanic Americans
Dysbiosis
Term Birth
Metagenomics
Reproductive Health
Lactobacillus
Women's Health
Social Class
Gestational Age
Pregnant Women

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Serrano, M. G., Parikh, H. I., Brooks, J. P., Edwards, D. J., Arodz, T. J., Edupuganti, L., ... Buck, G. A. (2019). Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy. Nature medicine. https://doi.org/10.1038/s41591-019-0465-8

Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy. / Serrano, Myrna G.; Parikh, Hardik I.; Brooks, J. Paul; Edwards, David J.; Arodz, Tom J.; Edupuganti, Laahirie; Huang, Bernice; Girerd, Philippe H.; Bokhari, Yahya A.; Bradley, Steven P.; Brooks, Jamie L.; Dickinson, Molly R.; Drake, Jennifer I.; Duckworth, Robert A.; Fong, Stephen S.; Glascock, Abigail L.; Jean, Sophonie; Jimenez, Nicole R.; Khoury, Joseph; Koparde, Vishal N.; Lara, Ana M.; Lee, Vladimir; Matveyev, Andrey V.; Milton, Sarah H.; Mistry, Shreni D.; Rozycki, Sarah K.; Sheth, Nihar U.; Smirnova, Ekaterina; Vivadelli, Stephany C.; Wijesooriya, N. Romesh; Xu, Jie; Xu, Ping; Chaffin, Donald O.; Sexton, Amber L.; Gravett, Michael G.; Rubens, Craig E.; Hendricks-Muñoz, Karen D.; Jefferson, Kimberly K.; Strauss, Jerome F.; Fettweis, Jennifer M.; Buck, Gregory A.

In: Nature medicine, 01.01.2019.

Research output: Contribution to journalArticle

Serrano, MG, Parikh, HI, Brooks, JP, Edwards, DJ, Arodz, TJ, Edupuganti, L, Huang, B, Girerd, PH, Bokhari, YA, Bradley, SP, Brooks, JL, Dickinson, MR, Drake, JI, Duckworth, RA, Fong, SS, Glascock, AL, Jean, S, Jimenez, NR, Khoury, J, Koparde, VN, Lara, AM, Lee, V, Matveyev, AV, Milton, SH, Mistry, SD, Rozycki, SK, Sheth, NU, Smirnova, E, Vivadelli, SC, Wijesooriya, NR, Xu, J, Xu, P, Chaffin, DO, Sexton, AL, Gravett, MG, Rubens, CE, Hendricks-Muñoz, KD, Jefferson, KK, Strauss, JF, Fettweis, JM & Buck, GA 2019, 'Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy', Nature medicine. https://doi.org/10.1038/s41591-019-0465-8
Serrano MG, Parikh HI, Brooks JP, Edwards DJ, Arodz TJ, Edupuganti L et al. Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy. Nature medicine. 2019 Jan 1. https://doi.org/10.1038/s41591-019-0465-8
Serrano, Myrna G. ; Parikh, Hardik I. ; Brooks, J. Paul ; Edwards, David J. ; Arodz, Tom J. ; Edupuganti, Laahirie ; Huang, Bernice ; Girerd, Philippe H. ; Bokhari, Yahya A. ; Bradley, Steven P. ; Brooks, Jamie L. ; Dickinson, Molly R. ; Drake, Jennifer I. ; Duckworth, Robert A. ; Fong, Stephen S. ; Glascock, Abigail L. ; Jean, Sophonie ; Jimenez, Nicole R. ; Khoury, Joseph ; Koparde, Vishal N. ; Lara, Ana M. ; Lee, Vladimir ; Matveyev, Andrey V. ; Milton, Sarah H. ; Mistry, Shreni D. ; Rozycki, Sarah K. ; Sheth, Nihar U. ; Smirnova, Ekaterina ; Vivadelli, Stephany C. ; Wijesooriya, N. Romesh ; Xu, Jie ; Xu, Ping ; Chaffin, Donald O. ; Sexton, Amber L. ; Gravett, Michael G. ; Rubens, Craig E. ; Hendricks-Muñoz, Karen D. ; Jefferson, Kimberly K. ; Strauss, Jerome F. ; Fettweis, Jennifer M. ; Buck, Gregory A. / Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy. In: Nature medicine. 2019.
@article{6d6c47e5312a49628540cdf7a8539c2c,
title = "Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy",
abstract = "The microbiome of the female reproductive tract has implications for women’s reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.",
author = "Serrano, {Myrna G.} and Parikh, {Hardik I.} and Brooks, {J. Paul} and Edwards, {David J.} and Arodz, {Tom J.} and Laahirie Edupuganti and Bernice Huang and Girerd, {Philippe H.} and Bokhari, {Yahya A.} and Bradley, {Steven P.} and Brooks, {Jamie L.} and Dickinson, {Molly R.} and Drake, {Jennifer I.} and Duckworth, {Robert A.} and Fong, {Stephen S.} and Glascock, {Abigail L.} and Sophonie Jean and Jimenez, {Nicole R.} and Joseph Khoury and Koparde, {Vishal N.} and Lara, {Ana M.} and Vladimir Lee and Matveyev, {Andrey V.} and Milton, {Sarah H.} and Mistry, {Shreni D.} and Rozycki, {Sarah K.} and Sheth, {Nihar U.} and Ekaterina Smirnova and Vivadelli, {Stephany C.} and Wijesooriya, {N. Romesh} and Jie Xu and Ping Xu and Chaffin, {Donald O.} and Sexton, {Amber L.} and Gravett, {Michael G.} and Rubens, {Craig E.} and Hendricks-Mu{\~n}oz, {Karen D.} and Jefferson, {Kimberly K.} and Strauss, {Jerome F.} and Fettweis, {Jennifer M.} and Buck, {Gregory A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1038/s41591-019-0465-8",
language = "English (US)",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

AU - Serrano, Myrna G.

AU - Parikh, Hardik I.

AU - Brooks, J. Paul

AU - Edwards, David J.

AU - Arodz, Tom J.

AU - Edupuganti, Laahirie

AU - Huang, Bernice

AU - Girerd, Philippe H.

AU - Bokhari, Yahya A.

AU - Bradley, Steven P.

AU - Brooks, Jamie L.

AU - Dickinson, Molly R.

AU - Drake, Jennifer I.

AU - Duckworth, Robert A.

AU - Fong, Stephen S.

AU - Glascock, Abigail L.

AU - Jean, Sophonie

AU - Jimenez, Nicole R.

AU - Khoury, Joseph

AU - Koparde, Vishal N.

AU - Lara, Ana M.

AU - Lee, Vladimir

AU - Matveyev, Andrey V.

AU - Milton, Sarah H.

AU - Mistry, Shreni D.

AU - Rozycki, Sarah K.

AU - Sheth, Nihar U.

AU - Smirnova, Ekaterina

AU - Vivadelli, Stephany C.

AU - Wijesooriya, N. Romesh

AU - Xu, Jie

AU - Xu, Ping

AU - Chaffin, Donald O.

AU - Sexton, Amber L.

AU - Gravett, Michael G.

AU - Rubens, Craig E.

AU - Hendricks-Muñoz, Karen D.

AU - Jefferson, Kimberly K.

AU - Strauss, Jerome F.

AU - Fettweis, Jennifer M.

AU - Buck, Gregory A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The microbiome of the female reproductive tract has implications for women’s reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.

AB - The microbiome of the female reproductive tract has implications for women’s reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.

UR - http://www.scopus.com/inward/record.url?scp=85066496978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066496978&partnerID=8YFLogxK

U2 - 10.1038/s41591-019-0465-8

DO - 10.1038/s41591-019-0465-8

M3 - Article

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

ER -