Racial heterogeneity of HIV antigenemia in people with HIV infection

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the prevalence of HIV p24 antigenemia in black and white US patients with HIV infection. The prevalence of HIV antigenemia increased with severity of HIV disease (P < 0.001). In all clinical categories, whites were more likely to be HIV-antigenemic than blacks (overall prevalence 38 versus 18%; P < 0.01). Anti-p24 antibodies were detected in a higher proportion of blacks (84%) than whites (65%; P = 0.02). Blacks had significantly higher total serum immunoglobulin levels than whites (median 3.8 versus 3.2 mg/dl; P < 0.00001). Racial differences in HIV antigen expression may result from differences in humoral response to HIV infection. These differences should be considered when HIV antigen is used as a surrogate marker in clinical trials.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalAIDS
Volume5
Issue number2
DOIs
StatePublished - Feb 1991

Keywords

  • HIV antigen
  • Race
  • Serology
  • p24 antibody
  • p24 antigen

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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