Abstract
Objective: This study aimed to compare COVID-19 positivity by HIV status and race/ethnicity using data from the U.S. National COVID Cohort Collaborative (N3C). Methods: The N3C cohort (≥ 18 years) includes patients with any encounter after 1/1/2020 with SARS-CoV-2 laboratory tests. Detailed electronic medical records are centralized and harmonized across health-care organizations (34 sites). COVID-19 diagnosis was defined by RT-PCR or antibody testing. HIV infection was defined by standard diagnostic codes within 2 years prior to COVID-19 testing. Descriptive statistics and multivariable logistic regression were utilized to compare COVID-19 positivity and HIV status by patient’s race/ethnicity. Results: Over 2.1 million patients were captured in the N3C as of 01/29/2021, of whom 372,716 (15%) were positive for COVID-19; 17,820 (0.7%) were PLWH of whom 2428 (13.6%) tested positive for COVID-19. COVID-19 positive PLWH were more likely to be 30+ years of age (90% vs. 70%; χ2p < 0.001), male (67% vs. 46%, χ2p < 0.001), and Black (44% vs. 15%, χ2p < 0.001) compared to HIV-negative patients. Compared to non-Hispanic/Latinx (NH)-White PLWH, NH-Black (aOR: 1.59, 95% CI: 1.37–1.86), Latinx (aOR: 2.17, 95% CI: 1.68–2.83), and NH-Asian (aOR: 2.18, 95% CI: 1.30–3.63) PLWH were more likely to have COVID-19 after adjustment for age, sex, and CharlsonDeyo comorbidity score. Conclusion: PLWH and minoritized communities, including NH-Black and Latinx or Hispanic adults, appear to be disproportionately impacted by the COVID-19 pandemic.
Original language | English (US) |
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Pages (from-to) | 462-466 |
Number of pages | 5 |
Journal | International Journal of STD and AIDS |
Volume | 33 |
Issue number | 5 |
DOIs | |
State | Published - Apr 2022 |
Keywords
- COVID-19
- Immunosuppression
- SARS-CoV-2 virus
- racial ethnic disparities
- social determinants of health
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Pharmacology (medical)
- Infectious Diseases
- Dermatology