Racial differences of lipoprotein subclass distributions in postmenopausal women

Amit N. Vora, Pamela Ouyang, Vera Bittner, Jean Claude Tardif, David D. Waters, Dhananjay Vaidya

Research output: Contribution to journalArticle

Abstract

Background: We assessed racial differences in lipoprotein particle size, a marker of atherosclerosis risk, among women with coronary disease. Methods: We studied 378 women (33% non- White, predominantly African American) at the baseline visit of the Women's Angiographic Vitamin and Estrogen Trial (WAVE), a multi- center trial of hormone replacement and antioxidant vitamin therapy in postmenopausal women with established coronary artery disease. Average particle sizes for high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein were measured by nuclear magnetic resonance in these women, and angiography was performed at baseline and followup. Results: Adjusted for age, race, diabetes, smoking, blood pressure, and use of lipid- lowering and antihypertensive medications, non-White women had larger LDL particle size (difference.2 nm, 95% CI.1-.3 nm) and HDL particle size (difference.2 nm, 95% CI.1-.2 nm). Neither angiographic disease progression nor survival without myocardial infarction (median follow-up time of 2.8 years) was associated with lipoprotein particle size or race. Conclusions: Non-White women have a less atherogenic profile of lipoprotein particle sizes than do White women. However, this difference did not affect event-free survival or angiographic progression of coronary atherosclerosis.

Original languageEnglish (US)
Pages (from-to)176-180
Number of pages5
JournalEthnicity and Disease
Volume18
Issue number2
StatePublished - Mar 1 2008

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Keywords

  • Lipoprotein Subclass Distributions
  • Postmenopausal Period
  • Race Differences

ASJC Scopus subject areas

  • Epidemiology

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