TY - JOUR
T1 - Racial differences of lipoprotein subclass distributions in postmenopausal women
AU - Vora, Amit N.
AU - Ouyang, Pamela
AU - Bittner, Vera
AU - Tardif, Jean Claude
AU - Waters, David D.
AU - Vaidya, Dhananjay
PY - 2008/3/1
Y1 - 2008/3/1
N2 - Background: We assessed racial differences in lipoprotein particle size, a marker of atherosclerosis risk, among women with coronary disease. Methods: We studied 378 women (33% non- White, predominantly African American) at the baseline visit of the Women's Angiographic Vitamin and Estrogen Trial (WAVE), a multi- center trial of hormone replacement and antioxidant vitamin therapy in postmenopausal women with established coronary artery disease. Average particle sizes for high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein were measured by nuclear magnetic resonance in these women, and angiography was performed at baseline and followup. Results: Adjusted for age, race, diabetes, smoking, blood pressure, and use of lipid- lowering and antihypertensive medications, non-White women had larger LDL particle size (difference.2 nm, 95% CI.1-.3 nm) and HDL particle size (difference.2 nm, 95% CI.1-.2 nm). Neither angiographic disease progression nor survival without myocardial infarction (median follow-up time of 2.8 years) was associated with lipoprotein particle size or race. Conclusions: Non-White women have a less atherogenic profile of lipoprotein particle sizes than do White women. However, this difference did not affect event-free survival or angiographic progression of coronary atherosclerosis.
AB - Background: We assessed racial differences in lipoprotein particle size, a marker of atherosclerosis risk, among women with coronary disease. Methods: We studied 378 women (33% non- White, predominantly African American) at the baseline visit of the Women's Angiographic Vitamin and Estrogen Trial (WAVE), a multi- center trial of hormone replacement and antioxidant vitamin therapy in postmenopausal women with established coronary artery disease. Average particle sizes for high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein were measured by nuclear magnetic resonance in these women, and angiography was performed at baseline and followup. Results: Adjusted for age, race, diabetes, smoking, blood pressure, and use of lipid- lowering and antihypertensive medications, non-White women had larger LDL particle size (difference.2 nm, 95% CI.1-.3 nm) and HDL particle size (difference.2 nm, 95% CI.1-.2 nm). Neither angiographic disease progression nor survival without myocardial infarction (median follow-up time of 2.8 years) was associated with lipoprotein particle size or race. Conclusions: Non-White women have a less atherogenic profile of lipoprotein particle sizes than do White women. However, this difference did not affect event-free survival or angiographic progression of coronary atherosclerosis.
KW - Lipoprotein Subclass Distributions
KW - Postmenopausal Period
KW - Race Differences
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M3 - Article
C2 - 18507270
AN - SCOPUS:47749127380
VL - 18
SP - 176
EP - 180
JO - Ethnicity and Disease
JF - Ethnicity and Disease
SN - 1049-510X
IS - 2
ER -