Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women

Sally P. Stabler, Robert H. Allen, Linda P Fried, Marco Pahor, Steven J. Kittner, Brenda W J H Penninx, Jack M. Guralnik

Research output: Contribution to journalArticle

Abstract

Background: Many previous investigations of cobalamin and folate status were performed in white populations. Objective: Our objective was to determine whether there are racial differences in the prevalence of cobalamin and folate deficiency. Design: The study was a cross-sectional comparison of baseline serum cobalamin, folate, methylmalonic acid (MMA), total homocysteine (tHcy), and creatinine concentrations, complete blood count, and vitamin supplementation in 550 white and 212 African American subjects from a cohort of physically disabled older women. Results: The mean (±SD) serum MMA concentration was significantly higher in whites than in African Americans: 284 ± 229 compared with 218 ± 158 nmol/L (P = 0.0001). tHcy concentration was higher in African Americans than in whites: 12.4 ± 7.0 compared with 10.9 ± 4.6 μmol/L (P = 0.001). Serum cobalamin was lower in whites (P = 0.0002). Cobalamin deficiency (serum cobalamin 271 nmol/L) was more frequent in the white women (19% compared with 8%; P <0.0003). Folate deficiency (serum folate 13.9 μmol/L, and MMA 85 y, African American race, serum creatinine >90 μmol/L, and high MMA concentration were all significantly correlated with higher tHcy. Creatinine > 90 μmol/L, white race, and folate concentration were positively associated with MMA concentration. Conclusions: Cobalamin deficiency with elevated serum MMA concentration is more prevalent in elderly white than in African American women and elevated serum tHcy and folate deficiency are more prevalent in elderly African American than in white women.

Original languageEnglish (US)
Pages (from-to)911-919
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume70
Issue number5
StatePublished - Nov 1999
Externally publishedYes

Fingerprint

vitamin B12
Vitamin B 12
Methylmalonic Acid
methylmalonic acid
Folic Acid
folic acid
blood serum
African Americans
homocysteine
Homocysteine
Serum
creatinine
Creatinine
Blood Cell Count
Disabled Persons
Vitamins
vitamins
blood
Population

Keywords

  • Cobalamin
  • Elderly
  • Folate
  • Homocysteine
  • Methylmalonic acid
  • Multivitamin use
  • Race
  • Women

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Stabler, S. P., Allen, R. H., Fried, L. P., Pahor, M., Kittner, S. J., Penninx, B. W. J. H., & Guralnik, J. M. (1999). Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. American Journal of Clinical Nutrition, 70(5), 911-919.

Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. / Stabler, Sally P.; Allen, Robert H.; Fried, Linda P; Pahor, Marco; Kittner, Steven J.; Penninx, Brenda W J H; Guralnik, Jack M.

In: American Journal of Clinical Nutrition, Vol. 70, No. 5, 11.1999, p. 911-919.

Research output: Contribution to journalArticle

Stabler, SP, Allen, RH, Fried, LP, Pahor, M, Kittner, SJ, Penninx, BWJH & Guralnik, JM 1999, 'Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women', American Journal of Clinical Nutrition, vol. 70, no. 5, pp. 911-919.
Stabler, Sally P. ; Allen, Robert H. ; Fried, Linda P ; Pahor, Marco ; Kittner, Steven J. ; Penninx, Brenda W J H ; Guralnik, Jack M. / Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. In: American Journal of Clinical Nutrition. 1999 ; Vol. 70, No. 5. pp. 911-919.
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