Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians

Ge Liu, Ben Allen, Oscar Lopez, Howard Aizenstein, Robert Boudreau, Anne Newman, Kristine Yaffe, Stephen Kritchevsky, Lenore Launer, Suzanne Satterfield, Eleanor Marie Simonsick, Caterina Rosano

Research output: Contribution to journalArticle

Abstract

Objective: To quantify racial differences in brain structural characteristics in white and black octogenarians, and to examine whether these characteristics contribute to cognition. Methods: Cross-sectional study of 283 adults 79-89 years old (59.4% white;42.0% women) with data on gray matter integrity via diffusion tensor imaging (mean diffusivity), gray matter atrophy (GMA), white matter hyperintensities (WMH), literacy, smoking, drinking, income, hypertension and diabetes. Participants were recruited from an ongoing epidemiological study of older adults living in the community with a range of chronic conditions, physical and cognitive function. Standardized betas (sβ) of neuroimaging markers predicting Digit Symbol Substitution Test (DSST) and Modified Mini-Mental State Examination (3MS) scores were computed in multivariable regression models stratified by race. Results: Compared to whites, blacks had lower DSST (p=0.001) and lower 3MS (p=0.006), but also lower mean diffusivity (i.e. higher gray matter microstructural integrity, p=0.032), independent of gender, income, literacy, body mass index, diabetes and drinking habits. Racial differences were not significant for WMH (p=0.062) or GMA (p=0.4). Among blacks, mean diffusivity and WMH were associated with DSST (sβ=-.209, p=0.037and -.211, p=.038, respectively) independent of each other and other covariates; among whites, mean diffusivity, but not WMH, was significantly associated with DSST and 3MS (sβ =-.277, p=.002 and -.250, p=0.029, respectively). Conclusions: In this cohort of octogenarians living in the community, blacks appeared to have higher microstructural integrity of gray matter as compared to whites. This neuroimaging marker was related to higher cognition even in the presence of WMH and other cardiovascular conditions. If confirmed, these findings suggest microstructural gray matter integrity may be a target to improve cognition, especially among blacks who survive to very old age with a range of chronic cardiovascular conditions.

Original languageEnglish (US)
Pages (from-to)648-654
Number of pages7
JournalCurrent Alzheimer Research
Volume12
Issue number7
StatePublished - 2015
Externally publishedYes

Fingerprint

Cognition
Neuroimaging
Drinking
Atrophy
Diffusion Tensor Imaging
Habits
Gray Matter
hydroquinone
Epidemiologic Studies
Body Mass Index
Cross-Sectional Studies
Smoking
White Matter
Hypertension
Brain
Literacy

Keywords

  • Brain MRI
  • Cognitive aging
  • DTI
  • Racial differences

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Liu, G., Allen, B., Lopez, O., Aizenstein, H., Boudreau, R., Newman, A., ... Rosano, C. (2015). Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians. Current Alzheimer Research, 12(7), 648-654.

Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians. / Liu, Ge; Allen, Ben; Lopez, Oscar; Aizenstein, Howard; Boudreau, Robert; Newman, Anne; Yaffe, Kristine; Kritchevsky, Stephen; Launer, Lenore; Satterfield, Suzanne; Simonsick, Eleanor Marie; Rosano, Caterina.

In: Current Alzheimer Research, Vol. 12, No. 7, 2015, p. 648-654.

Research output: Contribution to journalArticle

Liu, G, Allen, B, Lopez, O, Aizenstein, H, Boudreau, R, Newman, A, Yaffe, K, Kritchevsky, S, Launer, L, Satterfield, S, Simonsick, EM & Rosano, C 2015, 'Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians', Current Alzheimer Research, vol. 12, no. 7, pp. 648-654.
Liu G, Allen B, Lopez O, Aizenstein H, Boudreau R, Newman A et al. Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians. Current Alzheimer Research. 2015;12(7):648-654.
Liu, Ge ; Allen, Ben ; Lopez, Oscar ; Aizenstein, Howard ; Boudreau, Robert ; Newman, Anne ; Yaffe, Kristine ; Kritchevsky, Stephen ; Launer, Lenore ; Satterfield, Suzanne ; Simonsick, Eleanor Marie ; Rosano, Caterina. / Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians. In: Current Alzheimer Research. 2015 ; Vol. 12, No. 7. pp. 648-654.
@article{e78cb91fec424de8b35a0e608c78a9fb,
title = "Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians",
abstract = "Objective: To quantify racial differences in brain structural characteristics in white and black octogenarians, and to examine whether these characteristics contribute to cognition. Methods: Cross-sectional study of 283 adults 79-89 years old (59.4{\%} white;42.0{\%} women) with data on gray matter integrity via diffusion tensor imaging (mean diffusivity), gray matter atrophy (GMA), white matter hyperintensities (WMH), literacy, smoking, drinking, income, hypertension and diabetes. Participants were recruited from an ongoing epidemiological study of older adults living in the community with a range of chronic conditions, physical and cognitive function. Standardized betas (sβ) of neuroimaging markers predicting Digit Symbol Substitution Test (DSST) and Modified Mini-Mental State Examination (3MS) scores were computed in multivariable regression models stratified by race. Results: Compared to whites, blacks had lower DSST (p=0.001) and lower 3MS (p=0.006), but also lower mean diffusivity (i.e. higher gray matter microstructural integrity, p=0.032), independent of gender, income, literacy, body mass index, diabetes and drinking habits. Racial differences were not significant for WMH (p=0.062) or GMA (p=0.4). Among blacks, mean diffusivity and WMH were associated with DSST (sβ=-.209, p=0.037and -.211, p=.038, respectively) independent of each other and other covariates; among whites, mean diffusivity, but not WMH, was significantly associated with DSST and 3MS (sβ =-.277, p=.002 and -.250, p=0.029, respectively). Conclusions: In this cohort of octogenarians living in the community, blacks appeared to have higher microstructural integrity of gray matter as compared to whites. This neuroimaging marker was related to higher cognition even in the presence of WMH and other cardiovascular conditions. If confirmed, these findings suggest microstructural gray matter integrity may be a target to improve cognition, especially among blacks who survive to very old age with a range of chronic cardiovascular conditions.",
keywords = "Brain MRI, Cognitive aging, DTI, Racial differences",
author = "Ge Liu and Ben Allen and Oscar Lopez and Howard Aizenstein and Robert Boudreau and Anne Newman and Kristine Yaffe and Stephen Kritchevsky and Lenore Launer and Suzanne Satterfield and Simonsick, {Eleanor Marie} and Caterina Rosano",
year = "2015",
language = "English (US)",
volume = "12",
pages = "648--654",
journal = "Current Alzheimer Research",
issn = "1567-2050",
publisher = "Bentham Science Publishers B.V.",
number = "7",

}

TY - JOUR

T1 - Racial differences in gray matter integrity by diffusion tensor in black and white octogenarians

AU - Liu, Ge

AU - Allen, Ben

AU - Lopez, Oscar

AU - Aizenstein, Howard

AU - Boudreau, Robert

AU - Newman, Anne

AU - Yaffe, Kristine

AU - Kritchevsky, Stephen

AU - Launer, Lenore

AU - Satterfield, Suzanne

AU - Simonsick, Eleanor Marie

AU - Rosano, Caterina

PY - 2015

Y1 - 2015

N2 - Objective: To quantify racial differences in brain structural characteristics in white and black octogenarians, and to examine whether these characteristics contribute to cognition. Methods: Cross-sectional study of 283 adults 79-89 years old (59.4% white;42.0% women) with data on gray matter integrity via diffusion tensor imaging (mean diffusivity), gray matter atrophy (GMA), white matter hyperintensities (WMH), literacy, smoking, drinking, income, hypertension and diabetes. Participants were recruited from an ongoing epidemiological study of older adults living in the community with a range of chronic conditions, physical and cognitive function. Standardized betas (sβ) of neuroimaging markers predicting Digit Symbol Substitution Test (DSST) and Modified Mini-Mental State Examination (3MS) scores were computed in multivariable regression models stratified by race. Results: Compared to whites, blacks had lower DSST (p=0.001) and lower 3MS (p=0.006), but also lower mean diffusivity (i.e. higher gray matter microstructural integrity, p=0.032), independent of gender, income, literacy, body mass index, diabetes and drinking habits. Racial differences were not significant for WMH (p=0.062) or GMA (p=0.4). Among blacks, mean diffusivity and WMH were associated with DSST (sβ=-.209, p=0.037and -.211, p=.038, respectively) independent of each other and other covariates; among whites, mean diffusivity, but not WMH, was significantly associated with DSST and 3MS (sβ =-.277, p=.002 and -.250, p=0.029, respectively). Conclusions: In this cohort of octogenarians living in the community, blacks appeared to have higher microstructural integrity of gray matter as compared to whites. This neuroimaging marker was related to higher cognition even in the presence of WMH and other cardiovascular conditions. If confirmed, these findings suggest microstructural gray matter integrity may be a target to improve cognition, especially among blacks who survive to very old age with a range of chronic cardiovascular conditions.

AB - Objective: To quantify racial differences in brain structural characteristics in white and black octogenarians, and to examine whether these characteristics contribute to cognition. Methods: Cross-sectional study of 283 adults 79-89 years old (59.4% white;42.0% women) with data on gray matter integrity via diffusion tensor imaging (mean diffusivity), gray matter atrophy (GMA), white matter hyperintensities (WMH), literacy, smoking, drinking, income, hypertension and diabetes. Participants were recruited from an ongoing epidemiological study of older adults living in the community with a range of chronic conditions, physical and cognitive function. Standardized betas (sβ) of neuroimaging markers predicting Digit Symbol Substitution Test (DSST) and Modified Mini-Mental State Examination (3MS) scores were computed in multivariable regression models stratified by race. Results: Compared to whites, blacks had lower DSST (p=0.001) and lower 3MS (p=0.006), but also lower mean diffusivity (i.e. higher gray matter microstructural integrity, p=0.032), independent of gender, income, literacy, body mass index, diabetes and drinking habits. Racial differences were not significant for WMH (p=0.062) or GMA (p=0.4). Among blacks, mean diffusivity and WMH were associated with DSST (sβ=-.209, p=0.037and -.211, p=.038, respectively) independent of each other and other covariates; among whites, mean diffusivity, but not WMH, was significantly associated with DSST and 3MS (sβ =-.277, p=.002 and -.250, p=0.029, respectively). Conclusions: In this cohort of octogenarians living in the community, blacks appeared to have higher microstructural integrity of gray matter as compared to whites. This neuroimaging marker was related to higher cognition even in the presence of WMH and other cardiovascular conditions. If confirmed, these findings suggest microstructural gray matter integrity may be a target to improve cognition, especially among blacks who survive to very old age with a range of chronic cardiovascular conditions.

KW - Brain MRI

KW - Cognitive aging

KW - DTI

KW - Racial differences

UR - http://www.scopus.com/inward/record.url?scp=84952642782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952642782&partnerID=8YFLogxK

M3 - Article

C2 - 25387332

AN - SCOPUS:84952642782

VL - 12

SP - 648

EP - 654

JO - Current Alzheimer Research

JF - Current Alzheimer Research

SN - 1567-2050

IS - 7

ER -