Abstract
Dietary factors mediate racial disparities in hypertension. However, the physiological mechanisms underlying this relationship are incompletely understood. We sought to assess the association between 1-methylhistidine (1-MH), a metabolite marker of animal protein consumption, and blood pressure (BP) in a community-based cohort of black and white middle-aged adults. Methods: This analysis consisted of 655 participants of the Bogalusa Heart Study (25% black, 61% women, aged 34-58 years) who were not taking antihypertensive medication. Fasting serum 1-MH was measured using liquid chromatography-tandem mass spectroscopy. Animal food intakes were quantified by food-frequency questionnaires. Multivariable linear regression assessed the association between 1-MH and BP in combined and racestratified analyses, adjusting for demographic, dietary, and cardiometabolic factors. Results: A significant dose-response relationship was observed for the association of red meat (P-trend <0.01) and poultry (P-trend=0.03) intake with serum 1-MH among all individuals. Serum 1-MH, per standard deviation increase, had a significant positive association with SBP (b=3.4±1.6mmHg, P=0.04) and DBP (b=2.0±1.1mmHg, P=0.05) in black participants, whereas no appreciable association was observed in white participants. Among a subgroup of black participants with repeat outcome measures (median follow-up=3.0 years), one standard deviation increase in 1-MH conferred a 3.1 and 2.2mmHg higher annual increase in SBP (P=0.03) and DBP (P=0.03), respectively. Conclusion: Serum 1-MH associates with higher SBP and DBP in blacks, but not whites. These results suggest a utility for further assessing the role of dietary 1-MH among individuals with hypertension to help minimize racial disparities in cardiovascular health.
Original language | English (US) |
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Pages (from-to) | 2435-2442 |
Number of pages | 8 |
Journal | Journal of hypertension |
Volume | 38 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2020 |
Keywords
- 1-Methylhistidine
- African Americans
- blood pressure
- diet
- hypertension
- metabolomics
- methylhistidines
- race factors
- red meat
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine