TY - JOUR
T1 - Race, ethnicity and benign prostatic hyperplasia in the health professionals follow-up study
AU - Platz, Elizabeth A.
AU - Kawachi, Ichiro
AU - Rimm, Eric B.
AU - Willett, Walter C.
AU - Giovannucci, Edward
N1 - Funding Information:
Supported by Public Health Service Grant CA55075 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services; Grant HL35464 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, and Grant DK45779 from the National Institute for Diabetes and Digestive and Kidney Diseases.
PY - 2000/2
Y1 - 2000/2
N2 - Purpose: We examined whether the prevalence of benign prostatic hyperplasia (BPH) varies by racial or ethnic origin in a large cohort of American male health professionals. Materials and Methods: Included in our study were 1,508 men who underwent surgery for BPH between 1986 and 1994, and 1,837 with high moderate to severe lower urinary tract symptoms assessed by the American Urological Association symptom index in 1992 or 1994. 'Noncases' comprised 23,246 asymptomatic participants. Self-reported major ancestry was black in 201 men, Asian in 413, other origin in 604 and white in 25,373. White heritage was further classified as southern European in 6,408 men, Scandinavian in 2,951 and other white in 16,014. The relative risk of BPH and 95% confidence intervals (CI) adjusted for age, body mass index, alcohol consumption, smoking and physical activity were calculated by logistic regression. Results: Black men were not at increased risk for BPH (relative risk 0.85, 95% CI 0.55 to 1.31) compared with white men. Asian men were less likely to have undergone BPH surgery (relative risk 0.41, 95% CI 0.21 to 0.82), although the relative risk for symptoms was similar to that of white men. White men whose major ancestry was southern European were at modestly higher risk for BPH surgery (relative risk 1.28, 95% CI 1.12 to 1.46) and symptoms (relative risk 1.34, 95% CI 1.20 to 1.50), whereas men of Scandinavian heritage were at slightly decreased risk for symptoms than those of other white heritages. Conclusions: Racial and ethnic variation is evident in the incidence of BPH surgery and symptom severity. Whether this observed variation reflects underlying biological phenomena rather than differences in symptom tolerance requires further exploration.
AB - Purpose: We examined whether the prevalence of benign prostatic hyperplasia (BPH) varies by racial or ethnic origin in a large cohort of American male health professionals. Materials and Methods: Included in our study were 1,508 men who underwent surgery for BPH between 1986 and 1994, and 1,837 with high moderate to severe lower urinary tract symptoms assessed by the American Urological Association symptom index in 1992 or 1994. 'Noncases' comprised 23,246 asymptomatic participants. Self-reported major ancestry was black in 201 men, Asian in 413, other origin in 604 and white in 25,373. White heritage was further classified as southern European in 6,408 men, Scandinavian in 2,951 and other white in 16,014. The relative risk of BPH and 95% confidence intervals (CI) adjusted for age, body mass index, alcohol consumption, smoking and physical activity were calculated by logistic regression. Results: Black men were not at increased risk for BPH (relative risk 0.85, 95% CI 0.55 to 1.31) compared with white men. Asian men were less likely to have undergone BPH surgery (relative risk 0.41, 95% CI 0.21 to 0.82), although the relative risk for symptoms was similar to that of white men. White men whose major ancestry was southern European were at modestly higher risk for BPH surgery (relative risk 1.28, 95% CI 1.12 to 1.46) and symptoms (relative risk 1.34, 95% CI 1.20 to 1.50), whereas men of Scandinavian heritage were at slightly decreased risk for symptoms than those of other white heritages. Conclusions: Racial and ethnic variation is evident in the incidence of BPH surgery and symptom severity. Whether this observed variation reflects underlying biological phenomena rather than differences in symptom tolerance requires further exploration.
KW - Ethnic groups
KW - Prostate
KW - Prostatic hyperplasia
KW - Racial stocks
KW - Risk factors
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U2 - 10.1016/S0022-5347(05)67909-8
DO - 10.1016/S0022-5347(05)67909-8
M3 - Article
C2 - 10647663
AN - SCOPUS:0033969077
SN - 0022-5347
VL - 163
SP - 490
EP - 495
JO - Journal of Urology
JF - Journal of Urology
IS - 2
ER -