Rabeprazole: A pharmacologic and clinical review for acid-related disorders

Alia Dadabhai, Frank K. Friedenberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Rabeprazole is a proton pump inhibitor that can be used in the treatment of acid-peptic-related disorders (gastroesophageal reflux disease [GERD], duodenal ulcer, gastric ulcer, gastric acid hypersecretory syndromes) and Helicobacter pylori. Pharmacodynamic data has demonstrated that rabeprazole, with a high pKa of ∼ 5.0, can be activated at a higher pH than other proton pump inhibitors. This possibly results in faster onset of action. Owing to its non-enzymatic pathway of metabolism, rabeprazole is also less influenced by genetic polymorphisms of the CYP2C19, which others proton pump inhibitors are dependent on. In a 2-week, placebo-controlled trial, rabeprazole was both rapid and effective in relieving heartburn on day 1 of therapy and improved other GERD-related symptoms including regurgitation, belching, bloating, early satiety and nausea. For oesophageal reflux disease without erosions both 10 and 20 mg of rabeprazole are equivalent and better than placebo at 2 and 4 weeks. An on-demand approach to non-erosive reflux disease with 10 mg of rabeprazole has also been documented as superior to placebo. Some success in the treatment of extra-oesophageal manifestations of GERD, such as asthma and chronic laryngitis, has also been achieved with rabeprazole. Overall, rabeprazole with very few side effects is a safe and efficacious medication for acid suppression therapy.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalExpert Opinion on Drug Safety
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Acid-related disorders
  • Proton pump inhibitors
  • Rabeprazole

ASJC Scopus subject areas

  • Pharmacology (medical)

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