Rabbit antithymocyte globulin is more beneficial in standard kidney than in extended donor recipients

Karen L. Hardinger, Daniel C. Brennan, Mark A. Schnitzler

Research output: Contribution to journalArticle

Abstract

BACKGROUND.: In a randomized, international study comparing rabbit antithymocyte globulin (TMG) and basiliximab (BAS) induction in renal transplant recipients at risk for delayed graft function or acute rejection (n=278), TMG was associated with less acute rejection at 1 year. METHODS.: This study analyzed outcomes stratified by standard criteria donor (SCD), extended criteria donor (ECD), and hypertensive donor. Data-capture limitations necessitated defining ECD as donor age more than 60 years or 50 to 60 years with hypertension and renal insufficiency. RESULTS.: Seventy-five recipients received ECD-kidneys (28.4% TMG vs. 25.6% BAS, P≤NS) and 203 recipients received SCD-kidneys (72.6% TMG vs. 74.4% BAS, P≤NS). Recipients of an ECD or hypertensive donor-kidney had similar outcomes between treatment groups. Recipients of an SCD-kidney treated with TMG had less rejection (odds ratio [OR] 0.48). Recipients of a normotensive donor-kidney treated with TMG had less rejection (OR 0.56). Recipients of a normotensive, SCD-kidney treated with TMG had less rejection (OR 0.47) and death (OR 0.17) than their counterparts treated with BAS. CONCLUSIONS.: Contrary to its perceived niche in recipients of ECD-kidneys, TMG was most beneficial in patients who received a normotensive, deceased SCD kidney.

Original languageEnglish (US)
Pages (from-to)1372-1376
Number of pages5
JournalTransplantation
Volume87
Issue number9
DOIs
StatePublished - May 15 2009
Externally publishedYes

Keywords

  • Basiliximab
  • ECD-kidneys
  • Thymoglobulin

ASJC Scopus subject areas

  • Transplantation

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