R-Ras protein inhibits autophosphorylation of vascular endothelial growth factor receptor 2 in endothelial cells and suppresses receptor activation in tumor vasculature

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Abstract

Background: Excessive stimulation of endothelial cells by VEGF is a major cause of aberrant angiogenesis and leaky blood vessels in various medical conditions. Results: The Small GTPase R-Ras inhibits VEGF-induced internalization and tyrosine phosphorylation of VEGF receptor 2. Conclusion: R-Ras suppresses chronic and acute endothelial cell stimulation by VEGF. Significance: Our study identifies a mechanism of attenuating VEGF signaling by a Ras homolog and offers mechanistic insights into the regulation of angiogenesis by this small GTPase.

Original languageEnglish (US)
Pages (from-to)8133-8145
Number of pages13
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
Publication statusPublished - Mar 27 2015
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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