Quenching fire with fat: Phosphatidylinositides as putative regulators of pain

Research output: Contribution to journalReview articlepeer-review

Abstract

A novel mechanism has been proposed by which diverse inflammatory mediators might regulate thermally- or chemically-evoked pain. The constitutive repression of vanilloid receptor activity by phospholipid binding and its reversal by phospholipase C activation could explain how bradykinin, nerve growth factor and other agents augment pain sensation in the context of tissue injury.

Original languageEnglish (US)
Pages (from-to)602-604
Number of pages3
JournalTrends in Pharmacological Sciences
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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