TY - JOUR
T1 - Quenching fire with fat
T2 - Phosphatidylinositides as putative regulators of pain
AU - Caterina, Michael J.
N1 - Funding Information:
I thank H. Lee for critically reading this manuscript. This work was supported by a Research Scholars Grant RGS-01-063-01-CSM from the American Cancer Society.
PY - 2001/12/1
Y1 - 2001/12/1
N2 - A novel mechanism has been proposed by which diverse inflammatory mediators might regulate thermally- or chemically-evoked pain. The constitutive repression of vanilloid receptor activity by phospholipid binding and its reversal by phospholipase C activation could explain how bradykinin, nerve growth factor and other agents augment pain sensation in the context of tissue injury.
AB - A novel mechanism has been proposed by which diverse inflammatory mediators might regulate thermally- or chemically-evoked pain. The constitutive repression of vanilloid receptor activity by phospholipid binding and its reversal by phospholipase C activation could explain how bradykinin, nerve growth factor and other agents augment pain sensation in the context of tissue injury.
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U2 - 10.1016/S0165-6147(00)01862-9
DO - 10.1016/S0165-6147(00)01862-9
M3 - Review article
C2 - 11730954
AN - SCOPUS:0035576828
SN - 0165-6147
VL - 22
SP - 602
EP - 604
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 12
ER -