Quantitative whole-body parametric PET imaging incorporating a generalized Patlak model

Nicolas A. Karakatsanis, Yun Zhou, Martin Lodge, Michael E. Casey, Richard L. Wahl, Arman Rahmim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recently, we proposed a dynamic multi-bed PET imaging and analysis framework enabling clinically feasible whole-body parametric imaging. The standard Patlak linear graphical analysis allows for efficient modeling of whole-body tracer kinetics by directly estimating the uptake rate constant Ki and blood distribution volume V, based on a common two-compartment kinetic model. However, this model does not account for reversible uptake (e.g. dephosphorylation in FDG), thus underestimating Ki in this case, a finding observed in a number of published FDG or similar tracer studies. We propose a novel generalized PET parametric imaging framework enabling truly quantitative whole-body Patlak imaging including in regions exhibiting reversibility. For this purpose: a) an extended non-linear Patlak model has been utilized, enriched with the net efflux rate constant kloss, (b) a basis function method has been applied to linearize the estimation process through a computationally efficient algorithm, and (c) a hybrid Ki imaging technique is introduced based on the Patlak correlation-coefficient to enhance robustness to noise. Our evaluation included both simulated and real subject clinical studies. A set of published kinetic parameter values and the XCAT phantom were employed to generate realistic simulation data for 2 dynamic 7-bed acquisition protocols (0-45min and 30-90min post-injection). Quantitative analysis on the Ki images suggests superior quantitative performance of the generalized Patlak in comparison to the standard Patlak imaging in both acquisitions, even when kloss is comparable to Ki. In addition, validation on three dynamic whole-body patient datasets demonstrated clinical feasibility and increased focal uptake with potential for enhanced diagnosis and treatment response monitoring.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479905348
DOIs
StatePublished - 2013
Event2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of
Duration: Oct 27 2013Nov 2 2013

Other

Other2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
CountryKorea, Republic of
CitySeoul
Period10/27/1311/2/13

Fingerprint

Whole Body Imaging
Multimodal Imaging
tracers
beds
acquisition
kinetics
Nonlinear Dynamics
Blood Volume
efflux
Noise
data simulation
compartments
imaging techniques
correlation coefficients
quantitative analysis
blood
Injections
estimating
injection
evaluation

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Karakatsanis, N. A., Zhou, Y., Lodge, M., Casey, M. E., Wahl, R. L., & Rahmim, A. (2013). Quantitative whole-body parametric PET imaging incorporating a generalized Patlak model. In IEEE Nuclear Science Symposium Conference Record [6829042] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2013.6829042

Quantitative whole-body parametric PET imaging incorporating a generalized Patlak model. / Karakatsanis, Nicolas A.; Zhou, Yun; Lodge, Martin; Casey, Michael E.; Wahl, Richard L.; Rahmim, Arman.

IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 2013. 6829042.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Karakatsanis, NA, Zhou, Y, Lodge, M, Casey, ME, Wahl, RL & Rahmim, A 2013, Quantitative whole-body parametric PET imaging incorporating a generalized Patlak model. in IEEE Nuclear Science Symposium Conference Record., 6829042, Institute of Electrical and Electronics Engineers Inc., 2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013, Seoul, Korea, Republic of, 10/27/13. https://doi.org/10.1109/NSSMIC.2013.6829042
Karakatsanis NA, Zhou Y, Lodge M, Casey ME, Wahl RL, Rahmim A. Quantitative whole-body parametric PET imaging incorporating a generalized Patlak model. In IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc. 2013. 6829042 https://doi.org/10.1109/NSSMIC.2013.6829042
Karakatsanis, Nicolas A. ; Zhou, Yun ; Lodge, Martin ; Casey, Michael E. ; Wahl, Richard L. ; Rahmim, Arman. / Quantitative whole-body parametric PET imaging incorporating a generalized Patlak model. IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 2013.
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