Quantitative T2 mapping using accelerated 3D stack-of-spiral gradient echo readout

Ruoxun Zi, Dan Zhu, Qin Qin

Research output: Contribution to journalArticlepeer-review


Purpose: To develop a rapid T2 mapping protocol using optimized spiral acquisition, accelerated reconstruction, and model fitting. Materials and methods: A T2-prepared stack-of-spiral gradient echo (GRE) pulse sequence was applied. A model-based approach joined with compressed sensing was compared with the two methods applied separately for accelerated reconstruction and T2 mapping. A 2-parameter-weighted fitting method was compared with 2- or 3-parameter models for accurate T2 estimation under the influences of noise and B1 inhomogeneity. The performance was evaluated using both digital phantoms and healthy volunteers. Mitigating partial voluming with cerebrospinal fluid (CSF) was also tested.

Original languageEnglish (US)
Pages (from-to)138-147
Number of pages10
JournalMagnetic Resonance Imaging
StatePublished - Nov 2020


  • 2-parameter-weighted fitting
  • 3D stack-of-spiral
  • Cerebrospinal fluid nulling
  • Compressed sensing
  • Model-based reconstruction
  • T mapping

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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