TY - JOUR
T1 - Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)
AU - Ahn, Jiyoung
AU - Schumacher, Fredrick R.
AU - Berndt, Sonja I.
AU - Pfeiffer, Ruth
AU - Albanes, Demetrius
AU - Andriole, Gerald L.
AU - Ardanaz, Eva
AU - Boeing, Heiner
AU - Bueno-de-Mesquita, Bas
AU - Chanock, Stephen J.
AU - Clavel-Chapelon, Françoise
AU - Diver, W. Ryan
AU - Feigelson, Heather Spencer
AU - Gaziano, J. Michael
AU - Giovannucci, Edward
AU - Haiman, Christopher A.
AU - Henderson, Brian E.
AU - Hoover, Robert N.
AU - Kolonel, Laurence N.
AU - Kraft, Peter
AU - Ma, Jing
AU - Le Marchand, Loïc
AU - Overvad, Kim
AU - Palli, Domenico
AU - Stattin, Pär
AU - Stampfer, Meir
AU - Stram, Daniel O.
AU - Thomas, Gilles
AU - Thun, Michael J.
AU - Travis, Ruth C.
AU - Trichopoulos, Dimitrios
AU - Virtamo, Jarmo
AU - Weinstein, Stephanie J.
AU - Yeager, Meredith
AU - Kaaks, Rudolf
AU - Hunter, David J.
AU - Hayes, Richard B.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3α-androstanediol-glucuronide (N = 4767) and 17β-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 × 10 -21), consistent with previous studies, and testosterone (P = 7.54 × 10 -15), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 × 10 -6) and SRD5A2 with 3α-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 × 10 -6). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones.
AB - Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3α-androstanediol-glucuronide (N = 4767) and 17β-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 × 10 -21), consistent with previous studies, and testosterone (P = 7.54 × 10 -15), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 × 10 -6) and SRD5A2 with 3α-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 × 10 -6). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones.
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U2 - 10.1093/hmg/ddp302
DO - 10.1093/hmg/ddp302
M3 - Article
C2 - 19574343
AN - SCOPUS:70350787053
SN - 0964-6906
VL - 18
SP - 3749
EP - 3757
JO - Human molecular genetics
JF - Human molecular genetics
IS - 19
ER -