Quantitative study of optical and mechanical bone status using multispectral photoacoustics

Idan Steinberg, Nir Turko, Omri Levi, Israel Gannot, Avishay Eyal

Research output: Contribution to journalArticlepeer-review

Abstract

Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is enabled via a simultaneous measurement of the bone's optical properties as well as the speed of sound and ultrasonic attenuation in the bone. To test the method's quantitative predictions, a combined ultrasonic and photoacoustic system was developed. Excitation was performed optically via a portable triple laser-diode system and acoustically via a single element transducer. Additional dual transducers were used for detecting the acoustic waves that were generated by the two modalities. Both temporal and spectral parameters were compared between different excitation wavelengths and measurement modalities. Short photoacoustic excitation wavelengths allowed sensing of the cortical layer while longer wavelengths produced results which were compatible with the quantitative ultrasound measurements.

Original languageEnglish (US)
Pages (from-to)924-933
Number of pages10
JournalJournal of biophotonics
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • broadband ultrasonic attenuation
  • osteoporosis
  • photoacoustics
  • quantitative ultrasound
  • speed of sound

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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