Quantitative study of optical and mechanical bone status using multispectral photoacoustics

Idan Steinberg, Nir Turko, Omri Levi, Israel Gannot, Avishay Eyal

Research output: Contribution to journalArticle

Abstract

Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is enabled via a simultaneous measurement of the bone's optical properties as well as the speed of sound and ultrasonic attenuation in the bone. To test the method's quantitative predictions, a combined ultrasonic and photoacoustic system was developed. Excitation was performed optically via a portable triple laser-diode system and acoustically via a single element transducer. Additional dual transducers were used for detecting the acoustic waves that were generated by the two modalities. Both temporal and spectral parameters were compared between different excitation wavelengths and measurement modalities. Short photoacoustic excitation wavelengths allowed sensing of the cortical layer while longer wavelengths produced results which were compatible with the quantitative ultrasound measurements.

Original languageEnglish (US)
Pages (from-to)924-933
Number of pages10
JournalJournal of biophotonics
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Photoacoustic effect
bones
Bone
Ultrasonics
Bone and Bones
ultrasonics
Transducers
Wavelength
transducers
wavelengths
osteoporosis
excitation
public health
Semiconductor Lasers
acoustics
Acoustic wave velocity
pathology
Public health
Pathology
Medical problems

Keywords

  • broadband ultrasonic attenuation
  • osteoporosis
  • photoacoustics
  • quantitative ultrasound
  • speed of sound

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Quantitative study of optical and mechanical bone status using multispectral photoacoustics. / Steinberg, Idan; Turko, Nir; Levi, Omri; Gannot, Israel; Eyal, Avishay.

In: Journal of biophotonics, Vol. 9, No. 9, 01.09.2016, p. 924-933.

Research output: Contribution to journalArticle

Steinberg, Idan ; Turko, Nir ; Levi, Omri ; Gannot, Israel ; Eyal, Avishay. / Quantitative study of optical and mechanical bone status using multispectral photoacoustics. In: Journal of biophotonics. 2016 ; Vol. 9, No. 9. pp. 924-933.
@article{214403b25104431f89b88f01a5f993ce,
title = "Quantitative study of optical and mechanical bone status using multispectral photoacoustics",
abstract = "Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is enabled via a simultaneous measurement of the bone's optical properties as well as the speed of sound and ultrasonic attenuation in the bone. To test the method's quantitative predictions, a combined ultrasonic and photoacoustic system was developed. Excitation was performed optically via a portable triple laser-diode system and acoustically via a single element transducer. Additional dual transducers were used for detecting the acoustic waves that were generated by the two modalities. Both temporal and spectral parameters were compared between different excitation wavelengths and measurement modalities. Short photoacoustic excitation wavelengths allowed sensing of the cortical layer while longer wavelengths produced results which were compatible with the quantitative ultrasound measurements.",
keywords = "broadband ultrasonic attenuation, osteoporosis, photoacoustics, quantitative ultrasound, speed of sound",
author = "Idan Steinberg and Nir Turko and Omri Levi and Israel Gannot and Avishay Eyal",
year = "2016",
month = "9",
day = "1",
doi = "10.1002/jbio.201500206",
language = "English (US)",
volume = "9",
pages = "924--933",
journal = "Journal of Biophotonics",
issn = "1864-063X",
publisher = "Wiley-VCH Verlag",
number = "9",

}

TY - JOUR

T1 - Quantitative study of optical and mechanical bone status using multispectral photoacoustics

AU - Steinberg, Idan

AU - Turko, Nir

AU - Levi, Omri

AU - Gannot, Israel

AU - Eyal, Avishay

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is enabled via a simultaneous measurement of the bone's optical properties as well as the speed of sound and ultrasonic attenuation in the bone. To test the method's quantitative predictions, a combined ultrasonic and photoacoustic system was developed. Excitation was performed optically via a portable triple laser-diode system and acoustically via a single element transducer. Additional dual transducers were used for detecting the acoustic waves that were generated by the two modalities. Both temporal and spectral parameters were compared between different excitation wavelengths and measurement modalities. Short photoacoustic excitation wavelengths allowed sensing of the cortical layer while longer wavelengths produced results which were compatible with the quantitative ultrasound measurements.

AB - Osteoporosis is a major public health problem worldwide. Here, we present a quantitative multispectral photoacoustic method for the evaluation of bone pathologies which has significant advantages over pure ultrasonic or pure optical methods as it provides both molecular information and bone mechanical status. This is enabled via a simultaneous measurement of the bone's optical properties as well as the speed of sound and ultrasonic attenuation in the bone. To test the method's quantitative predictions, a combined ultrasonic and photoacoustic system was developed. Excitation was performed optically via a portable triple laser-diode system and acoustically via a single element transducer. Additional dual transducers were used for detecting the acoustic waves that were generated by the two modalities. Both temporal and spectral parameters were compared between different excitation wavelengths and measurement modalities. Short photoacoustic excitation wavelengths allowed sensing of the cortical layer while longer wavelengths produced results which were compatible with the quantitative ultrasound measurements.

KW - broadband ultrasonic attenuation

KW - osteoporosis

KW - photoacoustics

KW - quantitative ultrasound

KW - speed of sound

UR - http://www.scopus.com/inward/record.url?scp=85028273347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028273347&partnerID=8YFLogxK

U2 - 10.1002/jbio.201500206

DO - 10.1002/jbio.201500206

M3 - Article

C2 - 26487250

AN - SCOPUS:85028273347

VL - 9

SP - 924

EP - 933

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 9

ER -