Quantitative Spatial Profiling of TILs as the Next Step beyond PD-L1 Testing for Immune Checkpoint Blockade

Valsamo Anagnostou; Jason J. Luke

doi:10.1158/1078-0432.CCR-22-2277

Quantitative Spatial Profiling of TILs as the Next Step beyond PD-L1 Testing for Immune Checkpoint Blockade

Valsamo Anagnostou, Jason J. Luke

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Analysis of tumor-infiltrating lymphocyte (TIL) functional states, particularly tumor-reactive PD-1^T TILs, within specific spatial context, can serve as a biologically informed predictive marker of immunotherapy that may be superior to standard clinical biomarkers. High-plex quantitative immune cell phenotyping within their spatial context has tremendous potential in immuno-oncology.

Original language	English (US)
Pages (from-to)	4835-4837
Number of pages	3
Journal	Clinical Cancer Research
Volume	28
Issue number	22
DOIs	https://doi.org/10.1158/1078-0432.CCR-22-2277
State	Published - Nov 15 2022

ASJC Scopus subject areas

General Medicine

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abstract = "Analysis of tumor-infiltrating lymphocyte (TIL) functional states, particularly tumor-reactive PD-1T TILs, within specific spatial context, can serve as a biologically informed predictive marker of immunotherapy that may be superior to standard clinical biomarkers. High-plex quantitative immune cell phenotyping within their spatial context has tremendous potential in immuno-oncology.",

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Quantitative Spatial Profiling of TILs as the Next Step beyond PD-L1 Testing for Immune Checkpoint Blockade

Abstract

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