Quantitative shape analysis of the temporal and prefrontal lobes of schizophrenic patients: A magnetic resonance image study

M. F. Casanova, T. E. Goldberg, R. L. Suddath, D. G. Daniel, R. Rawlings, D. G. Lloyd, H. L. Loats, J. E. Kleinman, D. R. Weinberger

Research output: Contribution to journalArticle


In a recent quantitative neuroimaging study, the authors reported significant reduction in the gray matter volume of both temporal lobes of schizophrenic (SC) patients. In order to better elucidate the nature of this finding (i.e., diffuse vs. focal), we analyzed the shape of the temporal lobes of 17 SC patients and an equal number of age-sex matched controls. Our shape analysis was able to discriminate between a significant number of SC and control patients based on the Fourier harmonic amplitudes of both the middle and posterior levels of the temporal lobes. These results are consistent with bilateral focal or multifocal distortions of the temporal lobes of SC patients. A similar shape analysis of the prefrontal lobes showed no significant conformational differences between the groups. The basis of this quantitative shape analysis (the Fourier expansion series) and the method by which it can be applied are explained in detail.

Original languageEnglish (US)
Pages (from-to)363-372
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - Jan 1 1990
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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