Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest

Delphine Heimburger, Michel Durand, Lucie Gaide-Chevronnay, Geraldine Dessertaine, Pierre Henri Moury, Pierre Bouzat, Pierre Albaladejo, Jean Francois Payen

Research output: Contribution to journalArticle

Abstract

Background: Predicting outcome after cardiac arrest (CA) is particularly difficult when therapeutic hypothermia (TH) is used. We investigated the performance of quantitative pupillometry and transcranial Doppler (TCD) in this context. Methods: This prospective observational study included 82 post-CA patients. Quantitative assessment of pupillary light reflex (PLR) and TCD measurements of the two middle cerebral arteries were performed at admission (day 1) and after 24. h (day 2) during TH (33-35. °C) and sedation. Neurological outcome was assessed at 3 months using cerebral performance category (CPC) scores; patients were classified as having good (CPC 1-2) or poor (CPC 3-5) outcome. Prognostic performance was analyzed using area under the receiver operating characteristic curve (AUC-ROC). Results: Patients with good outcome (n = 27) had higher PLR amplitude than patients with poor outcome (n = 55) both at day 1, 13% (10-18) (median, 25th-75th percentile) vs. 8% (2-11) (P

Original languageEnglish (US)
JournalResuscitation
DOIs
StateAccepted/In press - Jan 10 2016
Externally publishedYes

Fingerprint

Heart Arrest
Hypothermia
Pupillary Reflex
Induced Hypothermia
ROC Curve
Light
Middle Cerebral Artery
Area Under Curve
Observational Studies
Prospective Studies

Keywords

  • Heart arrest
  • Hypothermia
  • Induced
  • Patient outcome assessment
  • Pupillary
  • Reflex
  • Transcranial Doppler sonography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine

Cite this

Heimburger, D., Durand, M., Gaide-Chevronnay, L., Dessertaine, G., Moury, P. H., Bouzat, P., ... Payen, J. F. (Accepted/In press). Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest. Resuscitation. https://doi.org/10.1016/j.resuscitation.2016.02.026

Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest. / Heimburger, Delphine; Durand, Michel; Gaide-Chevronnay, Lucie; Dessertaine, Geraldine; Moury, Pierre Henri; Bouzat, Pierre; Albaladejo, Pierre; Payen, Jean Francois.

In: Resuscitation, 10.01.2016.

Research output: Contribution to journalArticle

Heimburger, Delphine ; Durand, Michel ; Gaide-Chevronnay, Lucie ; Dessertaine, Geraldine ; Moury, Pierre Henri ; Bouzat, Pierre ; Albaladejo, Pierre ; Payen, Jean Francois. / Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest. In: Resuscitation. 2016.
@article{8b909b6535d04ce3a15f54011c874d4a,
title = "Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest",
abstract = "Background: Predicting outcome after cardiac arrest (CA) is particularly difficult when therapeutic hypothermia (TH) is used. We investigated the performance of quantitative pupillometry and transcranial Doppler (TCD) in this context. Methods: This prospective observational study included 82 post-CA patients. Quantitative assessment of pupillary light reflex (PLR) and TCD measurements of the two middle cerebral arteries were performed at admission (day 1) and after 24. h (day 2) during TH (33-35. °C) and sedation. Neurological outcome was assessed at 3 months using cerebral performance category (CPC) scores; patients were classified as having good (CPC 1-2) or poor (CPC 3-5) outcome. Prognostic performance was analyzed using area under the receiver operating characteristic curve (AUC-ROC). Results: Patients with good outcome (n = 27) had higher PLR amplitude than patients with poor outcome (n = 55) both at day 1, 13{\%} (10-18) (median, 25th-75th percentile) vs. 8{\%} (2-11) (P",
keywords = "Heart arrest, Hypothermia, Induced, Patient outcome assessment, Pupillary, Reflex, Transcranial Doppler sonography",
author = "Delphine Heimburger and Michel Durand and Lucie Gaide-Chevronnay and Geraldine Dessertaine and Moury, {Pierre Henri} and Pierre Bouzat and Pierre Albaladejo and Payen, {Jean Francois}",
year = "2016",
month = "1",
day = "10",
doi = "10.1016/j.resuscitation.2016.02.026",
language = "English (US)",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest

AU - Heimburger, Delphine

AU - Durand, Michel

AU - Gaide-Chevronnay, Lucie

AU - Dessertaine, Geraldine

AU - Moury, Pierre Henri

AU - Bouzat, Pierre

AU - Albaladejo, Pierre

AU - Payen, Jean Francois

PY - 2016/1/10

Y1 - 2016/1/10

N2 - Background: Predicting outcome after cardiac arrest (CA) is particularly difficult when therapeutic hypothermia (TH) is used. We investigated the performance of quantitative pupillometry and transcranial Doppler (TCD) in this context. Methods: This prospective observational study included 82 post-CA patients. Quantitative assessment of pupillary light reflex (PLR) and TCD measurements of the two middle cerebral arteries were performed at admission (day 1) and after 24. h (day 2) during TH (33-35. °C) and sedation. Neurological outcome was assessed at 3 months using cerebral performance category (CPC) scores; patients were classified as having good (CPC 1-2) or poor (CPC 3-5) outcome. Prognostic performance was analyzed using area under the receiver operating characteristic curve (AUC-ROC). Results: Patients with good outcome (n = 27) had higher PLR amplitude than patients with poor outcome (n = 55) both at day 1, 13% (10-18) (median, 25th-75th percentile) vs. 8% (2-11) (P

AB - Background: Predicting outcome after cardiac arrest (CA) is particularly difficult when therapeutic hypothermia (TH) is used. We investigated the performance of quantitative pupillometry and transcranial Doppler (TCD) in this context. Methods: This prospective observational study included 82 post-CA patients. Quantitative assessment of pupillary light reflex (PLR) and TCD measurements of the two middle cerebral arteries were performed at admission (day 1) and after 24. h (day 2) during TH (33-35. °C) and sedation. Neurological outcome was assessed at 3 months using cerebral performance category (CPC) scores; patients were classified as having good (CPC 1-2) or poor (CPC 3-5) outcome. Prognostic performance was analyzed using area under the receiver operating characteristic curve (AUC-ROC). Results: Patients with good outcome (n = 27) had higher PLR amplitude than patients with poor outcome (n = 55) both at day 1, 13% (10-18) (median, 25th-75th percentile) vs. 8% (2-11) (P

KW - Heart arrest

KW - Hypothermia

KW - Induced

KW - Patient outcome assessment

KW - Pupillary

KW - Reflex

KW - Transcranial Doppler sonography

UR - http://www.scopus.com/inward/record.url?scp=84961221367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961221367&partnerID=8YFLogxK

U2 - 10.1016/j.resuscitation.2016.02.026

DO - 10.1016/j.resuscitation.2016.02.026

M3 - Article

C2 - 26970030

AN - SCOPUS:84961221367

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

ER -