Quantitative proton MR spectroscopic imaging of the mesial temporal lobe

Atilla Arslanoglu, David Bonekamp, Peter B Barker, Alena Horská

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate variations in regional metabolite concentrations in the anterior mesial temporal lobe (ATL), and compare metabolite concentrations between the allocortex and neocortex using quantitative proton MR spectroscopic imaging (MRSI). Materials and Methods: Metabolite concentrations and ratios were measured in 20 healthy young subjects with the use of a multislice spin-echo (SE) sequence (TR/TE = 2300/280 msec). Quantitation of MRSI data was performed by means of the phantom replacement methodology. Results: The highest choline (Cho) concentration (4.1 ± 1.1 mM) was found in the ATL (P = 0.0015 compared to the middle mesial temporal lobe (MTL), and P = 0.0008 compared to the posterior mesial temporal lobe (PTL)). The ATL also had a higher Cho/creatine (Cr) ratio and a lower N-acetyl aspartate (NAA)/Cho ratio compared to other examined regions (P <0.0001 and P ≤ 0.052, respectively). In the allocortical regions, the average Cho concentration (3.5 ± 0.8 mM) was 68% higher, and the NAA concentration (9.5 ± 1.8 mM) was 13% lower than in the neocortex (P <10-6 and P <0.008, respectively). Cho/Cr was 64% higher, NAA/Cr 14% lower, and NAA/Cho 47% lower in the allocortex than in the neocortex (P <10-6, P = 0.013, and P <10-6, respectively). Conclusion: The mesial temporal lobe shows high levels of Cho, which presumably reflect a difference in cellular composition between the allocortex and neocortex. Regional metabolite variations must be considered when pathological conditions involving the mesial temporal lobe are evaluated.

Original languageEnglish (US)
Pages (from-to)772-778
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume20
Issue number5
DOIs
StatePublished - Nov 2004

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Temporal Lobe
Choline
Protons
Neocortex
Creatine
Cerebral Cortex
Healthy Volunteers
N-acetylaspartate

Keywords

  • Choline
  • Hippocampus
  • Magnetic resonance spectroscopy
  • Mesial temporal lobe
  • N-acetyl aspartate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Quantitative proton MR spectroscopic imaging of the mesial temporal lobe. / Arslanoglu, Atilla; Bonekamp, David; Barker, Peter B; Horská, Alena.

In: Journal of Magnetic Resonance Imaging, Vol. 20, No. 5, 11.2004, p. 772-778.

Research output: Contribution to journalArticle

Arslanoglu, Atilla ; Bonekamp, David ; Barker, Peter B ; Horská, Alena. / Quantitative proton MR spectroscopic imaging of the mesial temporal lobe. In: Journal of Magnetic Resonance Imaging. 2004 ; Vol. 20, No. 5. pp. 772-778.
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abstract = "Purpose: To evaluate variations in regional metabolite concentrations in the anterior mesial temporal lobe (ATL), and compare metabolite concentrations between the allocortex and neocortex using quantitative proton MR spectroscopic imaging (MRSI). Materials and Methods: Metabolite concentrations and ratios were measured in 20 healthy young subjects with the use of a multislice spin-echo (SE) sequence (TR/TE = 2300/280 msec). Quantitation of MRSI data was performed by means of the phantom replacement methodology. Results: The highest choline (Cho) concentration (4.1 ± 1.1 mM) was found in the ATL (P = 0.0015 compared to the middle mesial temporal lobe (MTL), and P = 0.0008 compared to the posterior mesial temporal lobe (PTL)). The ATL also had a higher Cho/creatine (Cr) ratio and a lower N-acetyl aspartate (NAA)/Cho ratio compared to other examined regions (P <0.0001 and P ≤ 0.052, respectively). In the allocortical regions, the average Cho concentration (3.5 ± 0.8 mM) was 68{\%} higher, and the NAA concentration (9.5 ± 1.8 mM) was 13{\%} lower than in the neocortex (P <10-6 and P <0.008, respectively). Cho/Cr was 64{\%} higher, NAA/Cr 14{\%} lower, and NAA/Cho 47{\%} lower in the allocortex than in the neocortex (P <10-6, P = 0.013, and P <10-6, respectively). Conclusion: The mesial temporal lobe shows high levels of Cho, which presumably reflect a difference in cellular composition between the allocortex and neocortex. Regional metabolite variations must be considered when pathological conditions involving the mesial temporal lobe are evaluated.",
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N2 - Purpose: To evaluate variations in regional metabolite concentrations in the anterior mesial temporal lobe (ATL), and compare metabolite concentrations between the allocortex and neocortex using quantitative proton MR spectroscopic imaging (MRSI). Materials and Methods: Metabolite concentrations and ratios were measured in 20 healthy young subjects with the use of a multislice spin-echo (SE) sequence (TR/TE = 2300/280 msec). Quantitation of MRSI data was performed by means of the phantom replacement methodology. Results: The highest choline (Cho) concentration (4.1 ± 1.1 mM) was found in the ATL (P = 0.0015 compared to the middle mesial temporal lobe (MTL), and P = 0.0008 compared to the posterior mesial temporal lobe (PTL)). The ATL also had a higher Cho/creatine (Cr) ratio and a lower N-acetyl aspartate (NAA)/Cho ratio compared to other examined regions (P <0.0001 and P ≤ 0.052, respectively). In the allocortical regions, the average Cho concentration (3.5 ± 0.8 mM) was 68% higher, and the NAA concentration (9.5 ± 1.8 mM) was 13% lower than in the neocortex (P <10-6 and P <0.008, respectively). Cho/Cr was 64% higher, NAA/Cr 14% lower, and NAA/Cho 47% lower in the allocortex than in the neocortex (P <10-6, P = 0.013, and P <10-6, respectively). Conclusion: The mesial temporal lobe shows high levels of Cho, which presumably reflect a difference in cellular composition between the allocortex and neocortex. Regional metabolite variations must be considered when pathological conditions involving the mesial temporal lobe are evaluated.

AB - Purpose: To evaluate variations in regional metabolite concentrations in the anterior mesial temporal lobe (ATL), and compare metabolite concentrations between the allocortex and neocortex using quantitative proton MR spectroscopic imaging (MRSI). Materials and Methods: Metabolite concentrations and ratios were measured in 20 healthy young subjects with the use of a multislice spin-echo (SE) sequence (TR/TE = 2300/280 msec). Quantitation of MRSI data was performed by means of the phantom replacement methodology. Results: The highest choline (Cho) concentration (4.1 ± 1.1 mM) was found in the ATL (P = 0.0015 compared to the middle mesial temporal lobe (MTL), and P = 0.0008 compared to the posterior mesial temporal lobe (PTL)). The ATL also had a higher Cho/creatine (Cr) ratio and a lower N-acetyl aspartate (NAA)/Cho ratio compared to other examined regions (P <0.0001 and P ≤ 0.052, respectively). In the allocortical regions, the average Cho concentration (3.5 ± 0.8 mM) was 68% higher, and the NAA concentration (9.5 ± 1.8 mM) was 13% lower than in the neocortex (P <10-6 and P <0.008, respectively). Cho/Cr was 64% higher, NAA/Cr 14% lower, and NAA/Cho 47% lower in the allocortex than in the neocortex (P <10-6, P = 0.013, and P <10-6, respectively). Conclusion: The mesial temporal lobe shows high levels of Cho, which presumably reflect a difference in cellular composition between the allocortex and neocortex. Regional metabolite variations must be considered when pathological conditions involving the mesial temporal lobe are evaluated.

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