Quantitative proteomics of auditory fear conditioning

Ingie Hong, Taewook Kang, Ki Na Yun, Yong Cheol Yoo, Sungmo Park, Jihye Kim, Bobae An, Sukwoon Song, Sukwon Lee, Jeongyeon Kim, Beomjong Song, Kyung Hoon Kwon, Jin Young Kim, Young Mok Park, Sukwoo Choi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Auditory fear conditioning is a well-characterized rodent learning model where a neutral auditory cue is paired with an aversive outcome to induce associative fear memory. The storage of long-term auditory fear memory requires long-term potentiation (LTP) in the lateral amygdala and de novo protein synthesis. Although many studies focused on individual proteins have shown their contribution to LTP and fear conditioning, non-biased genome-wide studies have only recently been possible with microarrays, which nevertheless fall short of measuring changes at the level of proteins. Here we employed quantitative proteomics to examine the expression of hundreds of proteins in the lateral amygdala in response to auditory fear conditioning. We found that various proteins previously implicated in LTP, learning and axon/dendrite growth were regulated by fear conditioning. A substantial number of proteins that were regulated by fear conditioning have not yet been studied specifically in learning or synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Apr 26 2013
Externally publishedYes


  • Auditory fear conditioning
  • Lateral amygdala
  • Long-term potentiation
  • Quantitative proteomics
  • TMT labeling

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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