Quantitative Proteomics for Clinical Translation

Zhaohui Chen, Jennifer E. Van Eyk

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

For precision medicine to be successful, the identification and measurement of proteins that are reflective of a personal health status is key both for the development and use of circulating biomarkers and to define mechanistic pathways involved in drug responses. Prior to clinical translation, it is essential to accurately and reproducibly detect protein concentrations, their isoforms or polymorphism expression, and the many potential cotranslational and posttranslational modifications on 100-10,000 individuals. Over the last 20 years, the proteomic field has matured with respect to its approaches, methods, and instrumentation to allow for increased number of measurements per analysis. Through the use of the current, state-of-art, high precision, and accuracy mass spectrometry technology, quantitative proteomics is becoming a quantitative method able to address the needs of precision medicine.

Original languageEnglish (US)
Title of host publicationGenomic and Precision Medicine
Subtitle of host publicationFoundations, Translation, and Implementation: Third Edition
PublisherElsevier Inc.
Pages79-87
Number of pages9
ISBN (Print)9780128006818
DOIs
StatePublished - Jan 1 2017

Keywords

  • Biomarkers
  • Disease modified
  • Mass spectrometry
  • Posttranslational modifications
  • Precision medicine
  • Proteomics
  • Quantitation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Chen, Z., & Van Eyk, J. E. (2017). Quantitative Proteomics for Clinical Translation. In Genomic and Precision Medicine: Foundations, Translation, and Implementation: Third Edition (pp. 79-87). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800681-8.00005-0