Quantitative Proteomics for Clinical Translation

For precision medicine to be successful, the identification and measurement of proteins that are reflective of a personal health status is key both for the development and use of circulating biomarkers and to define mechanistic pathways involved in drug responses. Prior to clinical translation, it is essential to accurately and reproducibly detect protein concentrations, their isoforms or polymorphism expression, and the many potential cotranslational and posttranslational modifications on 100-10,000 individuals. Over the last 20 years, the proteomic field has matured with respect to its approaches, methods, and instrumentation to allow for increased number of measurements per analysis. Through the use of the current, state-of-art, high precision, and accuracy mass spectrometry technology, quantitative proteomics is becoming a quantitative method able to address the needs of precision medicine.