Quantitative modeling of Cerenkov light production efficiency from medical radionuclides

Bradley J. Beattie, Daniel L.J. Thorek, Charles R. Schmidtlein, Keith S. Pentlow, John L. Humm, Andreas H. Hielscher

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency and other characteristics of the CR produced by various radionuclides would help in accessing the feasibility of proposed applications and guide the choice of radionuclides. To generate this information we developed models of CR production efficiency based on the Frank-Tamm equation and models of CR distribution based on Monte-Carlo simulations of photon and β particle transport. All models were validated against direct measurements using multiple radionuclides and then applied to a number of radionuclides commonly used in biomedical applications. We show that two radionuclides, Ac-225 and In-111, which have been reported to produce CR in water, do not in fact produce CR directly. We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use.

Original languageEnglish (US)
Article numbere31402
JournalPloS one
Volume7
Issue number2
DOIs
StatePublished - Feb 20 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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