Quantitative measurement of syndesmophyte volume and height in ankylosing spondylitis using CT

Sovira Tan, Jianhua Yao, John A. Flynn, Lawrence Yao, Michael M. Ward

Research output: Contribution to journalArticle

Abstract

Objective Syndesmophyte growth in ankylosing spondylitis can be difficult to measure using radiographs because of poor visualisation and semiquantitative scoring methods. We developed and tested the reliability and validity of a new computer-based method that fully quantifies syndesmophyte volumes and heights on CT scans. Methods In this developmental study, we performed lumbar spine CT scans on 38 patients and used our algorithm to compute syndesmophyte volume and height in four intervertebral disk spaces. To assess reliability, we compared results between two scans performed on the same day in nine patients. To assess validity, we compared computed measures to visual ratings of syndesmophyte volume and height on both CT scans and radiographs by two physician readers. Results Coefficients of variation for syndesmophyte volume and height, based on repeat scans, were 2.05% and 2.40%, respectively. Based on Bland-Altman analysis, an increase in syndesmophyte volume of more than 4% or in height of more than 0.20 mm represented a change greater than measurement error. Computed volumes and heights were strongly associated with physician ratings of syndesmophyte volume and height on visual examination of both the CT scans (p

Original languageEnglish (US)
Pages (from-to)544-550
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume73
Issue number3
DOIs
StatePublished - Mar 1 2014

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Computerized tomography
Ankylosing Spondylitis
Reproducibility of Results
Physicians
Intervertebral Disc
Spine
Research Design
Growth
Measurement errors
Visualization

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

Cite this

Quantitative measurement of syndesmophyte volume and height in ankylosing spondylitis using CT. / Tan, Sovira; Yao, Jianhua; Flynn, John A.; Yao, Lawrence; Ward, Michael M.

In: Annals of the Rheumatic Diseases, Vol. 73, No. 3, 01.03.2014, p. 544-550.

Research output: Contribution to journalArticle

Tan, Sovira ; Yao, Jianhua ; Flynn, John A. ; Yao, Lawrence ; Ward, Michael M. / Quantitative measurement of syndesmophyte volume and height in ankylosing spondylitis using CT. In: Annals of the Rheumatic Diseases. 2014 ; Vol. 73, No. 3. pp. 544-550.
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