Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI

Hanzhang Lu, Meng Law, Yulin Ge, Stephen M. Hesseltine, Otto Rapalino, Jens H. Jensen, Joseph A. Helpern

Research output: Contribution to journalArticle

Abstract

Although perfusion is of major interest for many spinal cord disorders, there is no established, reproducible technique for evaluating blood flow or blood volume of the spinal cord in humans. Here the first report of in vivo measurement of human spinal cord blood volume (scBV) is presented. An FDA-approved contrast agent, Gd-DTPA, was used as an intravascular agent for the cord parenchyma, and pre-/post-contrast vascular-space-occupancy (VASO) MRI experiments were performed to obtain a quantitative estimation of scBV in mL blood/100 mL tissue. VASO MRI was used because it does not rely on knowledge of an arterial input function, it avoids the imaging artifacts of single-shot echo planar imaging approaches, and it requires only relatively simple and direct calculations for scBV quantification. Preliminary tests at 1.5 T and 3 T gave mean ± SD scBV values of 4.3±0.7ml/100mL tissue (n = 6) and 4.4±0.7ml/100mL tissue (n=4), respectively, consistent with the expectation that the scBV values would not be field-dependent.

Original languageEnglish (US)
Pages (from-to)226-232
Number of pages7
JournalNMR in Biomedicine
Volume21
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Blood Volume
Fetal Blood
Magnetic resonance imaging
Blood Vessels
Spinal Cord
Blood
Tissue
Echo-Planar Imaging
Gadolinium DTPA
Spinal Cord Diseases
Imaging techniques
Artifacts
Contrast Media
Perfusion

Keywords

  • Contrast agent
  • Perfusion
  • Quantification
  • Spinal cord blood volume
  • Vascular-space-occupancy MRI

ASJC Scopus subject areas

  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Lu, H., Law, M., Ge, Y., Hesseltine, S. M., Rapalino, O., Jensen, J. H., & Helpern, J. A. (2008). Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI. NMR in Biomedicine, 21(3), 226-232. https://doi.org/10.1002/nbm.1185

Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI. / Lu, Hanzhang; Law, Meng; Ge, Yulin; Hesseltine, Stephen M.; Rapalino, Otto; Jensen, Jens H.; Helpern, Joseph A.

In: NMR in Biomedicine, Vol. 21, No. 3, 03.2008, p. 226-232.

Research output: Contribution to journalArticle

Lu, H, Law, M, Ge, Y, Hesseltine, SM, Rapalino, O, Jensen, JH & Helpern, JA 2008, 'Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI', NMR in Biomedicine, vol. 21, no. 3, pp. 226-232. https://doi.org/10.1002/nbm.1185
Lu, Hanzhang ; Law, Meng ; Ge, Yulin ; Hesseltine, Stephen M. ; Rapalino, Otto ; Jensen, Jens H. ; Helpern, Joseph A. / Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI. In: NMR in Biomedicine. 2008 ; Vol. 21, No. 3. pp. 226-232.
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