Quantitative measurement of cerebral blood volume using velocity-selective pulse trains

Research output: Contribution to journalArticle

Abstract

Purpose: To develop a non-contrast-enhanced MRI method for cerebral blood volume (CBV) mapping using velocity-selective (VS) pulse trains. Methods: The new pulse sequence applied velocity-sensitive gradient waveforms in the VS label modules and velocity-compensated ones in the control scans. Sensitivities to the gradient imperfections (e.g., eddy currents) were evaluated through phantom studies. CBV quantification procedures based on simulated labeling efficiencies for arteriolar, capillary, and venular blood as a function of cutoff velocity (Vc) are presented. Experiments were conducted on healthy volunteers at 3T to examine the effects of unbalanced diffusion weighting, cerebrospinal (CSF) contamination and variation of Vc. Results: Phantom results of the used VS pulse trains demonstrated robustness to eddy currents. The mean CBV values of gray matter and white matter for the experiments using Vc=3.5mm/s and velocity-compensated control with CSF-nulling were 5.1±0.6mL/100g and 2.4±0.2mL/100g, respectively, which were 23% and 32% lower than results from the experiment with velocity-insensitive control, corresponding to 29% and 25% lower in averaged temporal signal-to-noise ratio values. Conclusion: A novel technique using VS pulse trains was demonstrated for CBV mapping. The results were both qualitatively and quantitatively close to those from existing methods.

Original languageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - 2016

Fingerprint

Signal-To-Noise Ratio
Healthy Volunteers
Cerebral Blood Volume
Gray Matter
White Matter

Keywords

  • Arterial spin labeling
  • Cerebral blood volume
  • Eddy current
  • Velocity-selective pulse train

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Quantitative measurement of cerebral blood volume using velocity-selective pulse trains",
abstract = "Purpose: To develop a non-contrast-enhanced MRI method for cerebral blood volume (CBV) mapping using velocity-selective (VS) pulse trains. Methods: The new pulse sequence applied velocity-sensitive gradient waveforms in the VS label modules and velocity-compensated ones in the control scans. Sensitivities to the gradient imperfections (e.g., eddy currents) were evaluated through phantom studies. CBV quantification procedures based on simulated labeling efficiencies for arteriolar, capillary, and venular blood as a function of cutoff velocity (Vc) are presented. Experiments were conducted on healthy volunteers at 3T to examine the effects of unbalanced diffusion weighting, cerebrospinal (CSF) contamination and variation of Vc. Results: Phantom results of the used VS pulse trains demonstrated robustness to eddy currents. The mean CBV values of gray matter and white matter for the experiments using Vc=3.5mm/s and velocity-compensated control with CSF-nulling were 5.1±0.6mL/100g and 2.4±0.2mL/100g, respectively, which were 23{\%} and 32{\%} lower than results from the experiment with velocity-insensitive control, corresponding to 29{\%} and 25{\%} lower in averaged temporal signal-to-noise ratio values. Conclusion: A novel technique using VS pulse trains was demonstrated for CBV mapping. The results were both qualitatively and quantitatively close to those from existing methods.",
keywords = "Arterial spin labeling, Cerebral blood volume, Eddy current, Velocity-selective pulse train",
author = "Dexiang Liu and Feng Xu and Doris Lin and {Van Zijl}, {Peter C} and Qin Qin",
year = "2016",
doi = "10.1002/mrm.26515",
language = "English (US)",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",

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AU - Liu, Dexiang

AU - Xu, Feng

AU - Lin, Doris

AU - Van Zijl, Peter C

AU - Qin, Qin

PY - 2016

Y1 - 2016

N2 - Purpose: To develop a non-contrast-enhanced MRI method for cerebral blood volume (CBV) mapping using velocity-selective (VS) pulse trains. Methods: The new pulse sequence applied velocity-sensitive gradient waveforms in the VS label modules and velocity-compensated ones in the control scans. Sensitivities to the gradient imperfections (e.g., eddy currents) were evaluated through phantom studies. CBV quantification procedures based on simulated labeling efficiencies for arteriolar, capillary, and venular blood as a function of cutoff velocity (Vc) are presented. Experiments were conducted on healthy volunteers at 3T to examine the effects of unbalanced diffusion weighting, cerebrospinal (CSF) contamination and variation of Vc. Results: Phantom results of the used VS pulse trains demonstrated robustness to eddy currents. The mean CBV values of gray matter and white matter for the experiments using Vc=3.5mm/s and velocity-compensated control with CSF-nulling were 5.1±0.6mL/100g and 2.4±0.2mL/100g, respectively, which were 23% and 32% lower than results from the experiment with velocity-insensitive control, corresponding to 29% and 25% lower in averaged temporal signal-to-noise ratio values. Conclusion: A novel technique using VS pulse trains was demonstrated for CBV mapping. The results were both qualitatively and quantitatively close to those from existing methods.

AB - Purpose: To develop a non-contrast-enhanced MRI method for cerebral blood volume (CBV) mapping using velocity-selective (VS) pulse trains. Methods: The new pulse sequence applied velocity-sensitive gradient waveforms in the VS label modules and velocity-compensated ones in the control scans. Sensitivities to the gradient imperfections (e.g., eddy currents) were evaluated through phantom studies. CBV quantification procedures based on simulated labeling efficiencies for arteriolar, capillary, and venular blood as a function of cutoff velocity (Vc) are presented. Experiments were conducted on healthy volunteers at 3T to examine the effects of unbalanced diffusion weighting, cerebrospinal (CSF) contamination and variation of Vc. Results: Phantom results of the used VS pulse trains demonstrated robustness to eddy currents. The mean CBV values of gray matter and white matter for the experiments using Vc=3.5mm/s and velocity-compensated control with CSF-nulling were 5.1±0.6mL/100g and 2.4±0.2mL/100g, respectively, which were 23% and 32% lower than results from the experiment with velocity-insensitive control, corresponding to 29% and 25% lower in averaged temporal signal-to-noise ratio values. Conclusion: A novel technique using VS pulse trains was demonstrated for CBV mapping. The results were both qualitatively and quantitatively close to those from existing methods.

KW - Arterial spin labeling

KW - Cerebral blood volume

KW - Eddy current

KW - Velocity-selective pulse train

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