Quantitative measurement of cerebral blood volume using velocity-selective pulse trains

Research output: Contribution to journalArticle

Abstract

Purpose: To develop a non–contrast-enhanced MRI method for cerebral blood volume (CBV) mapping using velocity-selective (VS) pulse trains. Methods: The new pulse sequence applied velocity-sensitive gradient waveforms in the VS label modules and velocity-compensated ones in the control scans. Sensitivities to the gradient imperfections (e.g., eddy currents) were evaluated through phantom studies. CBV quantification procedures based on simulated labeling efficiencies for arteriolar, capillary, and venular blood as a function of cutoff velocity (Vc) are presented. Experiments were conducted on healthy volunteers at 3T to examine the effects of unbalanced diffusion weighting, cerebrospinal (CSF) contamination and variation of Vc. Results: Phantom results of the used VS pulse trains demonstrated robustness to eddy currents. The mean CBV values of gray matter and white matter for the experiments using Vc = 3.5 mm/s and velocity-compensated control with CSF-nulling were 5.1 ± 0.6 mL/100 g and 2.4 ± 0.2 mL/100 g, respectively, which were 23% and 32% lower than results from the experiment with velocity-insensitive control, corresponding to 29% and 25% lower in averaged temporal signal-to-noise ratio values. Conclusion: A novel technique using VS pulse trains was demonstrated for CBV mapping. The results were both qualitatively and quantitatively close to those from existing methods. Magn Reson Med 77:92–101, 2017.

Original languageEnglish (US)
Pages (from-to)92-101
Number of pages10
JournalMagnetic resonance in medicine
Volume77
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • arterial spin labeling
  • cerebral blood volume
  • eddy current
  • velocity-selective pulse train

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Quantitative measurement of cerebral blood volume using velocity-selective pulse trains'. Together they form a unique fingerprint.

  • Cite this