TY - JOUR
T1 - Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame
AU - Gröhn, Olli H.J.
AU - Lukkarinen, Jouko A.
AU - Silvennoinen, M. Johanna
AU - Pitkänen, Asla
AU - Van Zijl, Peter C.M.
AU - Kauppinen, Risto A.
PY - 1999
Y1 - 1999
N2 - Sensitivity of T1 in the rotating frame (T(1p)) to both transient cerebral ischemia and cortical hypoperfusion was studied in rats. T(1p) is believed to probe water in close contact with macromolecules, revealing water spins with restricted rotational mobility relative to bulk water. It is shown that T(1p) increases within minutes of occlusion, thereby demonstrating it as a new, sensitive indicator of ischemia. After reperfusion at 90 minutes of middle cerebral artery occlusion, T(1p) remains elevated or increases in tissue destined to neuronal damage but returns to the normal level if no neuronal damage develops within 24 hours. T(1p) determined during the first 2 hours of reperfusion shows a significant positive correlation with the ultimate neuronal damage score. However, T(1p) is not affected by acute hypoperfusion. These data show that, by combining three magnetic resonance imaging coefficients, i.e. T(1p), T2, and diffusion, viable hypoperfused areas that do not develop neuronal damage within 24 hours can be distinguished correctly from tissue already destined for neuronal damage.
AB - Sensitivity of T1 in the rotating frame (T(1p)) to both transient cerebral ischemia and cortical hypoperfusion was studied in rats. T(1p) is believed to probe water in close contact with macromolecules, revealing water spins with restricted rotational mobility relative to bulk water. It is shown that T(1p) increases within minutes of occlusion, thereby demonstrating it as a new, sensitive indicator of ischemia. After reperfusion at 90 minutes of middle cerebral artery occlusion, T(1p) remains elevated or increases in tissue destined to neuronal damage but returns to the normal level if no neuronal damage develops within 24 hours. T(1p) determined during the first 2 hours of reperfusion shows a significant positive correlation with the ultimate neuronal damage score. However, T(1p) is not affected by acute hypoperfusion. These data show that, by combining three magnetic resonance imaging coefficients, i.e. T(1p), T2, and diffusion, viable hypoperfused areas that do not develop neuronal damage within 24 hours can be distinguished correctly from tissue already destined for neuronal damage.
KW - Acute ischemia
KW - Brain
KW - Diffusion
KW - Magnetic resonance imaging
KW - Neuronal damage
KW - T relaxation
KW - T(1p) relaxation
UR - http://www.scopus.com/inward/record.url?scp=0345425800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345425800&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1522-2594(199908)42:2<268::AID-MRM8>3.0.CO;2-A
DO - 10.1002/(SICI)1522-2594(199908)42:2<268::AID-MRM8>3.0.CO;2-A
M3 - Article
C2 - 10440951
AN - SCOPUS:0345425800
SN - 0740-3194
VL - 42
SP - 268
EP - 276
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 2
ER -