Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame

Olli H.J. Gröhn, Jouko A. Lukkarinen, M. Johanna Silvennoinen, Asla Pitkänen, Peter C.M. Van Zijl, Risto A. Kauppinen

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Sensitivity of T1 in the rotating frame (T(1p)) to both transient cerebral ischemia and cortical hypoperfusion was studied in rats. T(1p) is believed to probe water in close contact with macromolecules, revealing water spins with restricted rotational mobility relative to bulk water. It is shown that T(1p) increases within minutes of occlusion, thereby demonstrating it as a new, sensitive indicator of ischemia. After reperfusion at 90 minutes of middle cerebral artery occlusion, T(1p) remains elevated or increases in tissue destined to neuronal damage but returns to the normal level if no neuronal damage develops within 24 hours. T(1p) determined during the first 2 hours of reperfusion shows a significant positive correlation with the ultimate neuronal damage score. However, T(1p) is not affected by acute hypoperfusion. These data show that, by combining three magnetic resonance imaging coefficients, i.e. T(1p), T2, and diffusion, viable hypoperfused areas that do not develop neuronal damage within 24 hours can be distinguished correctly from tissue already destined for neuronal damage.

Original languageEnglish (US)
Pages (from-to)268-276
Number of pages9
JournalMagnetic resonance in medicine
Volume42
Issue number2
DOIs
StatePublished - 1999

Keywords

  • Acute ischemia
  • Brain
  • Diffusion
  • Magnetic resonance imaging
  • Neuronal damage
  • T relaxation
  • T(1p) relaxation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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