TY - JOUR
T1 - Quantitative left ventricular contractility analysis under stress
T2 - A new practical approach in follow-up of hypertensive patients
AU - Yalçin, F.
AU - Yalçin, H.
AU - Küçükler, N.
AU - Abraham, T. P.
N1 - Funding Information:
FY is supported by American Government Fulbright Scholarship. He has accepted only research equipment support from Novartis Pharmaceuticals.
PY - 2011/10
Y1 - 2011/10
N2 - Excessive sympathetic activity and stress-induced left ventricular (LV) hypercontractility have been described in hypertensive LV hypertrophy. Recent quantitative data have shown that hypertensive LV hypertrophy is associated with preserved global LV function. However, progression of uncontrolled hypertension have detrimental effects on both the ejection fraction (EF) and LV contractile response to stress. Hypertensive LV hypertrophy has some common characteristics, including preserved global LV systolic function and LV volume with heart failure with preserved EF (HFPEF), which makes it difficult to differentiate between the two conditions at rest. Studies suggest that adopting an efficient antihypertensive therapy regimen may positively effect on the LV contractile capability in patients with long-standing hypertension. Evaluation of quantitative LV contractility under stress may be beneficial to differentiate between the hypertensive LV hypertrophy and HFPEF. It may also assist in developing a more effective modality in medical management of patients with hypertensive heart disease.
AB - Excessive sympathetic activity and stress-induced left ventricular (LV) hypercontractility have been described in hypertensive LV hypertrophy. Recent quantitative data have shown that hypertensive LV hypertrophy is associated with preserved global LV function. However, progression of uncontrolled hypertension have detrimental effects on both the ejection fraction (EF) and LV contractile response to stress. Hypertensive LV hypertrophy has some common characteristics, including preserved global LV systolic function and LV volume with heart failure with preserved EF (HFPEF), which makes it difficult to differentiate between the two conditions at rest. Studies suggest that adopting an efficient antihypertensive therapy regimen may positively effect on the LV contractile capability in patients with long-standing hypertension. Evaluation of quantitative LV contractility under stress may be beneficial to differentiate between the hypertensive LV hypertrophy and HFPEF. It may also assist in developing a more effective modality in medical management of patients with hypertensive heart disease.
KW - heart failure with preserved ejection fraction
KW - hypertensive heart disease
KW - stress-induced contractility
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U2 - 10.1038/jhh.2010.101
DO - 10.1038/jhh.2010.101
M3 - Review article
C2 - 21107433
AN - SCOPUS:80052876700
SN - 0950-9240
VL - 25
SP - 578
EP - 584
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
IS - 10
ER -