Quantitative ischemia detection during cardiac magnetic resonance stress testing by use of FastHARP

Dara Kraitchman, Smita Sampath, Ernesto Castillo, John A. Derbyshire, Raymond C. Boston, David A. Bluemke, Bernhard L. Gerber, Jerry Ladd Prince, Nael Fakhry Osman

Research output: Contribution to journalArticle

Abstract

Background - Because ECG alterations caused by ischemia cannot be reliably detected in the high-field MRI environment, detection of wall motion abnormalities is often used to ensure patient safety during stress testing. However, an experienced observer is needed to detect these abnormalities. In this study, we investigate the use of fast harmonic phase (FastHARP) MRI for the quantitative, operator-independent detection of the onset of ischemia during acute coronary occlusion. Methods and Results - Eight mongrel dogs underwent an acute 2-minute closed-chest coronary artery occlusion while continuous FastHARP images were acquired. Full regional wall strain was determined every other heartbeat in a single short-axis imaging slice. After 5 minutes of reperfusion, a second 2-minute ischemic episode was induced during the acquisition of conventional cine wall-motion images. The time at which ECG alterations were observed during the first ischemic period was recorded. The time from occlusion to the detection of ischemia, based on a consensus of 2 blinded observers, was determined for MRI, No significant ischemia was present in 2 animals. In the remaining animals, the onset of ischemia was detected significantly earlier by FastHARP than by cine MRI (9,5±5 versus 33±14 seconds, P

Original languageEnglish (US)
Pages (from-to)2025-2030
Number of pages6
JournalCirculation
Volume107
Issue number15
DOIs
StatePublished - Apr 22 2003

Fingerprint

Magnetic Resonance Spectroscopy
Ischemia
Coronary Occlusion
Electrocardiography
Cine Magnetic Resonance Imaging
Patient Safety
Reperfusion
Coronary Vessels
Thorax
Dogs

Keywords

  • Coronary disease
  • Ischemia
  • Magnetic resonance imaging
  • Myocardial contraction
  • Systole

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Quantitative ischemia detection during cardiac magnetic resonance stress testing by use of FastHARP. / Kraitchman, Dara; Sampath, Smita; Castillo, Ernesto; Derbyshire, John A.; Boston, Raymond C.; Bluemke, David A.; Gerber, Bernhard L.; Prince, Jerry Ladd; Osman, Nael Fakhry.

In: Circulation, Vol. 107, No. 15, 22.04.2003, p. 2025-2030.

Research output: Contribution to journalArticle

Kraitchman, Dara ; Sampath, Smita ; Castillo, Ernesto ; Derbyshire, John A. ; Boston, Raymond C. ; Bluemke, David A. ; Gerber, Bernhard L. ; Prince, Jerry Ladd ; Osman, Nael Fakhry. / Quantitative ischemia detection during cardiac magnetic resonance stress testing by use of FastHARP. In: Circulation. 2003 ; Vol. 107, No. 15. pp. 2025-2030.
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