Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease

Thomas J. Montine, Joseph F. Quinn, Kathleen S. Montine, Jeffrey A. Kaye, John C.S. Breitner

Research output: Contribution to journalArticle

Abstract

Dementia from Alzheimer's disease (AD) represents a significant and growing public health burden and presents a clear therapeutic imperative. Key to success in this undertaking will be biomarkers for the objective assessment of disease progression and response to therapeutics. Oxidative damage is one facet of AD pathogenesis for which there are experimentally validated quantitative in vivo biomarkers, the F2-isoprostanes (IsoPs). While plasma- or urine-based assays are desirable, consistent and reproducible cross-sectional data for increased F2-IsoPs in AD and mild cognitive impairment have been obtained only for CSF. In addition, measurement of CSF F2-IsoPs can increase the accuracy of laboratory-based classification of geriatric dementias, and have been used to assess objectively the response to anti-oxidant interventions in AD.

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalJournal of Alzheimer's Disease
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Biomarkers
  • F2-isoprostanes
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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