Quantitative histological changes produced in the tracheal mucosa of young chickens by the inhalation of sulfur dioxide in low concentrations

H. Okuyama, Y. Majima, A. M. Dannenberg, M. Suga, B. G. Bang, F. B. Bang

Research output: Contribution to journalArticle

Abstract

Chickens were exposed to SO2 in relatively low concentrations (3.4 to 18.5 parts per million (ppm)) for 1 to 14 days. A portion of their tracheas was embedded in water-soluble methacrylate, cut at 2 μm and stained with hematoxylin and eosin, Wright's stain, methyl green-pyronin, Alcian blue - periodic acid Schiff, and for acid phosphatase. An increase was found in (a) the mucosa to wall ratio; (b) the number of mucosal cells in mitosis; (c) the number of macrophages, lymphocytes, plasma cells, and neutrophils in the epithelium and lamina propria; and (d) the number of these infiltrating cells which contained acid phosphatase. The number of mucus- and seromucus-secreting cells and vasoamine-containing cells were sometimes increased, but not consistently. The percentage of cells containing sialidase-sensitive sialomucins was elevated, and the percentage of cells containing neutral mucins was reduced. These changes were only partly related to the SO2 concentration and the duration of SO2 exposure, in that increasing amounts of SO2 did not always cause increasing changes in the mucin composition. Evidently, the altered mucins sometimes protected against further mucin modification.

Original languageEnglish (US)
Pages (from-to)267-300
Number of pages34
JournalJournal of Environmental Science and Health Part C Environmental Health Sciences
Volume13
Issue number2
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Cancer Research
  • Health, Toxicology and Mutagenesis

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