Quantitative functional MRI of the visual cortex as a function of luminance contrast at 1.5 T

S. H. Faro, F. B. Mohamed, J. I. Tracy, A. Pinus, F. Lublin, R. Elfont, R. Koenigsberg, F. Y. Tsai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study examined the BOLD signal changes in primary visual cortex as a function of luminous contrast at 1.5 T in 4 normals and 2 patients with multiple sclerosis (MS) disease. Echo planar T2* weighted BOLD imaging experiments were performed using a 1.5 T Imager. Ten axial slices through the calcarine fissure were obtained. The imaging series consisted of alternations between a 20-second epoch of dark screen (rest) and a 20-second epoch of a flickering checkerboard (activation) repeated 6 times. Each imaging series utilized a stepwise, graded increase of eight different luminance contrast levels. A paired t-test was used to compare the control condition with each activation condition. The data shows a linear trend in the number of fMRI activated voxels within the visual cortex with increasing luminous contrast in normals and MS patients. This study demonstrates quantifiable changes in BOLD signal and a linear increase in activated voxels within the primary visual cortex with increasing luminous contrast.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Faro, S. H., Mohamed, F. B., Tracy, J. I., Pinus, A., Lublin, F., Elfont, R., Koenigsberg, R., & Tsai, F. Y. (1999). Quantitative functional MRI of the visual cortex as a function of luminance contrast at 1.5 T. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 2). IEEE.