Quantitative fluorescent imaging of specific markers of diseased tissue

Amir H. Gandjbakhche, Israel Gannot

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed a random walk theory to relate observable fluorescent intensities on tissue surfaces to the presence of several embedded fluorescent masses. This work is an extension of analysis previously carried out for an isolated fluorescent site. Results depend on the optical properties of tissue at the excitation and emission wavelengths, as well as on the location of fluorescent targets and positions of source and detector. Measurements on tissue-like phantoms were performed to test the theory. Analysis of fluorescent signals, performed in accordance with the theory, yields accurate information about the location of the targets. Prospects of a noninvasive quantitative fluorescent imaging system, to diagnose and monitor salivary glands disease, is presented.

Original languageEnglish (US)
Pages (from-to)914-921
Number of pages8
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume2
Issue number4
DOIs
StatePublished - Dec 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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