Quantitative evidence for revising the definition of primary graft dysfunction after lung transplant

Edward Cantu, Joshua M. Diamond, Yoshikazu Suzuki, Jared Lasky, Christian Schaufler, Brian Lim, Rupal Shah, Mary Porteous, David J. Lederer, Steven M. Kawut, Scott M. Palmer, Laurie D. Snyder, Matthew G. Hartwig, Vibha N. Lama, Sangeeta Bhorade, Christian Bermudez, Maria Crespo, John McDyer, Keith Wille, Jonathan B OrensPali Dedhiya Shah, Ann Weinacker, David Weill, David Wilkes, David Roe, Chadi Hage, Lorraine B. Ware, Scarlett L. Bellamy, Jason D. Christie

Research output: Contribution to journalArticle

Abstract

Rationale: Primary graft dysfunction (PGD) is a form of acute lung injury that occurs after lung transplantation. The definition of PGD was standardized in 2005. Since that time, clinical practice has evolved, and this definition is increasingly used as a primary endpoint for clinical trials; therefore, validation is warranted. Objectives: We sought to determine whether refinements to the 2005 consensus definition could further improve construct validity. Methods: Data from the Lung Transplant Outcomes Group multicenter cohort were used to compare variations on the PGD definition, including alternate oxygenation thresholds, inclusion of additional severity groups, and effects of procedure type and mechanical ventilation. Convergent and divergent validity were compared for mortality prediction and concurrent lung injury biomarker discrimination. Measurements and Main Results: A total of 1, 179 subjects from 10 centers were enrolled from 2007 to 2012. Median length of follow-up was 4 years (interquartile range = 2.4-5.9). No mortality differences were noted between no PGD (grade 0) and mild PGD (grade 1). Significantly better mortality discrimination was evident for all definitions using later time points (48, 72, or 48-72 hours; P < 0.001). Biomarker divergent discrimination was superior when collapsing grades 0 and 1. Additional severity grades, use of mechanical ventilation, and transplant procedure type had minimal or no effect on mortality or biomarker discrimination. Conclusions: The PGD consensus definition can be simplified by combining lower PGD grades. Construct validity of grading was present regardless of transplant procedure type or use of mechanical ventilation. Additional severity categories had minimal impact on mortality or biomarker discrimination.

Original languageEnglish (US)
Pages (from-to)235-243
Number of pages9
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume197
Issue number2
DOIs
StatePublished - Jan 15 2018

Keywords

  • Lung transplant
  • Lung transplant outcomes
  • Primary graft dysfunction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Quantitative evidence for revising the definition of primary graft dysfunction after lung transplant'. Together they form a unique fingerprint.

  • Cite this

    Cantu, E., Diamond, J. M., Suzuki, Y., Lasky, J., Schaufler, C., Lim, B., Shah, R., Porteous, M., Lederer, D. J., Kawut, S. M., Palmer, S. M., Snyder, L. D., Hartwig, M. G., Lama, V. N., Bhorade, S., Bermudez, C., Crespo, M., McDyer, J., Wille, K., ... Christie, J. D. (2018). Quantitative evidence for revising the definition of primary graft dysfunction after lung transplant. American Journal of Respiratory and Critical Care Medicine, 197(2), 235-243. https://doi.org/10.1164/rccm.201706-1140OC