Quantitative EEG in babies at risk for hypoxic ischemic encephalopathy after perinatal asphyxia

M. Hathi, D. L. Sherman, T. Inder, N. S. Rothman, M. Natarajan, C. Niesen, L. M. Korst, T. Pantano, A. Natarajan

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate an electroencephalography (EEG)-based index, the Cerebral Health Index in babies (CHI/b), for identification of neonates with high Sarnat scores and abnormal EEG as markers of hypoxic ischemic encephalopathy (HIE) after perinatal asphyxia. Study Design: This is a retrospective study using 30 min of EEG data collected from 20 term neonates with HIE and 20 neurologically normal neonates. The HIE diagnosis was made on clinical grounds based on history and examination findings. The maximum-modified clinical Sarnat score was used to grade HIE severity within 72 h of life. All neonates underwent 2-channel bedside EEG monitoring. A trained electroencephalographer blinded to clinical data visually classified each EEG as normal, mild or severely abnormal. The CHI/b was trained using data from Channel 1 and tested on Channel 2. Result: The CHI/b distinguished among HIE and controls (P <0.02) and among the three visually interpreted EEG categories (P <0.0002). It showed a sensitivity of 82.4% and specificity of 100% in detecting high grades of neonatal encephalopathy (Sarnat 2 and 3), with an area under the receiver operator characteristic (ROC) curve of 0.912. CHI/b also identified differences between normal vs mildly abnormal (P <0.005), mild vs severely abnormal (P <0.01) and normal vs severe (P <0.002) EEG groups. An ROC curve analysis showed that the optimal ability of CHI/b to discriminate poor outcome was 89.7% (sensitivity: 87.5%; specificity: 82.4%). Conclusion: The CHI/b identified neonates with high Sarnat scores and abnormal EEG. These results support its potential as an objective indicator of neurological injury in infants with HIE.

Original languageEnglish (US)
Pages (from-to)122-126
Number of pages5
JournalJournal of perinatology : official journal of the California Perinatal Association
Volume30
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Brain Hypoxia-Ischemia
Asphyxia
Electroencephalography
Health
Newborn Infant
Brain Diseases
Retrospective Studies
History
Sensitivity and Specificity
Wounds and Injuries

Keywords

  • Pattern recognition
  • Perinatal asphyxia
  • Sarnat score
  • Visual EEG

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Quantitative EEG in babies at risk for hypoxic ischemic encephalopathy after perinatal asphyxia. / Hathi, M.; Sherman, D. L.; Inder, T.; Rothman, N. S.; Natarajan, M.; Niesen, C.; Korst, L. M.; Pantano, T.; Natarajan, A.

In: Journal of perinatology : official journal of the California Perinatal Association, Vol. 30, No. 2, 02.2010, p. 122-126.

Research output: Contribution to journalArticle

Hathi, M, Sherman, DL, Inder, T, Rothman, NS, Natarajan, M, Niesen, C, Korst, LM, Pantano, T & Natarajan, A 2010, 'Quantitative EEG in babies at risk for hypoxic ischemic encephalopathy after perinatal asphyxia', Journal of perinatology : official journal of the California Perinatal Association, vol. 30, no. 2, pp. 122-126. https://doi.org/10.1038/jp.2009.130
Hathi, M. ; Sherman, D. L. ; Inder, T. ; Rothman, N. S. ; Natarajan, M. ; Niesen, C. ; Korst, L. M. ; Pantano, T. ; Natarajan, A. / Quantitative EEG in babies at risk for hypoxic ischemic encephalopathy after perinatal asphyxia. In: Journal of perinatology : official journal of the California Perinatal Association. 2010 ; Vol. 30, No. 2. pp. 122-126.
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