Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest

Hyun Chool Shin, Shanbao Tong, Soichiro Yamashita, Xiaofeng Jia, Romergryko Geocadin, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we provide a quantitative electroencephalogram (EEG) analysis to study the effect of hypothermia on the neurological recovery of brain after cardiac arrest. We hypothesize that the brain injury results in a reduction in information of the brain rhythm. To measure the information content of the EEG a new measure called information quantity (IQ), which is the Shannon entropy of decorrelated EEG signals, is developed. For decorrelating EEG signals, we use the discrete wavelet transform (DWT) which is known to have good decorrelating properties and to show a good match to the standard clinical bands in EEG. In simulation for measuring the amount of information, the IQ shows better tracking capability for dynamic amplitude change and frequency component change than conventional entropy-based measures. Experiments are carried out in rodents to monitor the neurological recovery after cardiac arrest. In addition, EEG signal recovery under normothermic (37°C) and hypothermic (33°C) resuscitation following 5, 7 and 9 minutes of cardiac arrest is recorded and analyzed. Experimental results show that the IQ is higher for hypothermic than normothermic rats. The results quantitatively support the hypothesis that hypothermia accelerates the recovery of brain injury after cardiac arrest.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages6229-6232
Number of pages4
DOIs
StatePublished - 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

Fingerprint

Electroencephalography
Brain
Hypothermia
Recovery
Entropy
Resuscitation
Discrete wavelet transforms
Rats
Experiments

ASJC Scopus subject areas

  • Bioengineering

Cite this

Shin, H. C., Tong, S., Yamashita, S., Jia, X., Geocadin, R., & Thakor, N. V. (2006). Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 6229-6232). [4030432] https://doi.org/10.1109/IEMBS.2006.260739

Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest. / Shin, Hyun Chool; Tong, Shanbao; Yamashita, Soichiro; Jia, Xiaofeng; Geocadin, Romergryko; Thakor, Nitish V.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 6229-6232 4030432.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shin, HC, Tong, S, Yamashita, S, Jia, X, Geocadin, R & Thakor, NV 2006, Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4030432, pp. 6229-6232, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.260739
Shin HC, Tong S, Yamashita S, Jia X, Geocadin R, Thakor NV. Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 6229-6232. 4030432 https://doi.org/10.1109/IEMBS.2006.260739
Shin, Hyun Chool ; Tong, Shanbao ; Yamashita, Soichiro ; Jia, Xiaofeng ; Geocadin, Romergryko ; Thakor, Nitish V. / Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. pp. 6229-6232
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