@article{79f29c11f1c54abcb735c029a8aa0724,
title = "Quantitative EEG and effect of hypothermia on brain recovery after cardiac arrest",
abstract = "In this paper, we provide a quantitative electroencephalogram (EEG) analysis to study the effect of hypothermia on the neurological recovery of brain after cardiac arrest. We hypothesize that the brain injury results in a reduction in information of the brain rhythm. To measure the information content of the EEG a new measure called information quantity (IQ), which is the Shannon entropy of decorrelated EEG signals, is developed. For decorrelating EEG signals, we use the discrete wavelet transform (DWT) which is known to have good decorrelating properties and to show a good match to the standard clinical bands in EEG. In measuring the amount of information, IQ shows better tracking capability for dynamic amplitude change and frequency component change than conventional entropy-based measures. Experiments are carried out in rodents (n = 30) to monitor the neurological recovery after cardiac arrest. In addition, EEG signal recovery under normothermic (37°C) and hypothermic (33°C) resuscitation following 5, 7, and 9 min of cardiac arrest is recorded and analyzed. Experimental results show that the IQ is greater for hypothermic than normothermic rats, with an IQ difference of more than 0.20 (0.20±0.11 is 95% condidence interval). The results quantitatively support the hypothesis that hypothermia accelerates the electrical recovery from brain injury after cardiac arrest.",
keywords = "Brain injury, Cardiac arrest, EEG, Entropy, Hypothermia, Wavelet",
author = "Shin, {Hyun Chool} and Shanbao Tong and Soichiro Yamashita and Xiaofeng Jia and Geocadin, {Romergryko G.} and Thakor, {Nitish V.}",
note = "Funding Information: Manuscript received March 9, 2005; revised October 22, 2005. This work was supported in part by the National Institutes of Health (NIH) under Grant HL71568 and Grant NS42640 and in part by Information and Telecommunication National Scholarship Program funded by the Ministry of Information and Communication (MIC), Republic of Korea. Asterisk indicates corresponding author. Funding Information: Dr. Thakor serves on the editorial boards of several journals and has been appointed as the incoming Editor in Chief of IEEE TRANSACTIONS ON NEURAL AND REHABILITATION ENGINEERING. He is a recipient of a Research Career Development Award from the National Institutes of Health and a Presidential Young Investigator Award from the National Science Foundation, and is a fellow of the American Institute of Medical and Biological Engineering and Founding Fellow of the Biomedical Engineering Society. He is also a recipient of the Centennial Medal from the University of Wisconsin School of Engineering, Honorary Membership from Alpha Eta Mu Beta Biomedical Engineering student Honor Society and Distinguished Service Award from IIT Bombay. Funding Information: Dr. Jia is a recipient of the Guanghua scholarship, Government Public scholarship, the Outstanding moral-intellectual-physical student, and the Outstanding graduate from Fudan University and National Educational Ministry Outstanding Postgraduate scholarship from Shanghai Medical University. He is a member of the Chinese Society of Microsurgery and member of Chinese Society of Orthopaedics.",
year = "2006",
month = jun,
doi = "10.1109/TBME.2006.873394",
language = "English (US)",
volume = "53",
pages = "1016--1023",
journal = "IEEE Transactions on Biomedical Engineering",
issn = "0018-9294",
publisher = "IEEE Computer Society",
number = "6",
}