Quantitative determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients

L. E. Delisi, D. R. Weinberger, S. Potkin, L. M. Neckers, D. J. Shiling, R. J. Wyatt

Research output: Contribution to journalArticlepeer-review

Abstract

Immunoglobulins, IgG, IgA and IgM were quantified in cerebrospinal fluid (CSF) and plasma from chronic schizophrenic patients and controls using an immunofluorescent antibody technique. A generalized reduction in immunoglobulin levels was observed in the schizophrenic patients compared with controls. While this study supports other reports of abnormal immune functioning in schizophrenia, it failed to replicate previous findings of elevations in CSF IgG and elevations in serum IgA. The aetiology and significance of these findings are hypothesized but remain elusive.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalUnknown Journal
Volume139
Issue number6
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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