Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain

Research output: Contribution to journalArticle

Abstract

Magnetization transfer (MT) imaging provides a unique method of tissue characterization by capitalizing on the interaction between solid-like tissue components and bulk water. We used a continuous-wave (CW) MT pulse sequence with low irradiation power to study healthy human brains in vivo at 3 T and quantified the asymmetry of the MT effects with respect to the water proton frequency. This asymmetry was found to be a difference of approximately a few percent from the water signal intensity, depending on both the RF irradiation power and the frequency offset. The experimental results could be quantitatively described by a modified two-pool MT model extended with a shift contribution for the semisolid pool with respect to water. For white matter, this shift was fitted to be 2.34 ± 0.17 ppm (N = 5) upfield from the water signal.

Original languageEnglish (US)
Pages (from-to)786-793
Number of pages8
JournalMagnetic resonance in medicine
Volume58
Issue number4
DOIs
StatePublished - Oct 2007

Keywords

  • Amide proton transfer
  • Asymmetry
  • CEST
  • Human brain
  • MT
  • Magnetization transfer
  • z-spectrum

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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