Quantitative comparisons of three automated methods for estimating intracranial volume: A study of 270 longitudinal magnetic resonance images

Xiaoyan Shang, Michelle C Carlson, Xiaoying Tang

Research output: Contribution to journalArticle

Abstract

Total intracranial volume (TIV) is often used as a measure of brain size to correct for individual variability in magnetic resonance imaging (MRI) based morphometric studies. An adjustment of TIV can greatly increase the statistical power of brain morphometry methods. As such, an accurate and precise TIV estimation is of great importance in MRI studies. In this paper, we compared three automated TIV estimation methods (multi-atlas likelihood fusion (MALF), Statistical Parametric Mapping 8 (SPM8) and FreeSurfer (FS)) using longitudinal T1-weighted MR images in a cohort of 70 older participants at elevated sociodemographic risk for Alzheimer's disease. Statistical group comparisons in terms of four different metrics were performed. Furthermore, sex, education level, and intervention status were investigated separately for their impacts on the TIV estimation performance of each method. According to our experimental results, MALF was the least susceptible to atrophy, while SPM8 and FS suffered a loss in precision. In group-wise analysis, MALF was the least sensitive method to group variation, whereas SPM8 was particularly sensitive to sex and FS was unstable with respect to education level. In terms of effectiveness, both MALF and SPM8 delivered a user-friendly performance, while FS was relatively computationally intensive.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume274
DOIs
StatePublished - Apr 30 2018

Keywords

  • Automated estimation
  • Freesurfer
  • Magnetic resonance imaging
  • Multi-atlas likelihood fusion
  • Statistical Parametric Mapping
  • Total intracranial volume

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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