Quantitative comparison of [18F]fallypride PET binding potential estimates using reference tissue models in rat brains

Dianne E. Lee, Siva Muthusamy, Dima A. Hammoud

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of our study was to compare commonly used mathematical models for analyzing dynamic [18F]fallypride PET data in rat brains when arterial input function is not available. For the quantification of dopamine D2/3 receptors, we compared the time activity curves (TACs) and binding potential estimates using several simplified methods, including the 1T simplified reference tissue model (SRTM), using 60 minutes versus 90 minutes of emission recording, the 2T Reference method, and the equilibrium concentration ratios. The reliability of fit of the tissue time activity curves (TACs) and the binding potential estimates were then compared.

Original languageEnglish (US)
Title of host publication2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781467398626
DOIs
Publication statusPublished - Oct 3 2016
Externally publishedYes
Event2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 - San Diego, United States
Duration: Oct 31 2015Nov 7 2015

Other

Other2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
CountryUnited States
CitySan Diego
Period10/31/1511/7/15

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ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging
  • Instrumentation

Cite this

Lee, D. E., Muthusamy, S., & Hammoud, D. A. (2016). Quantitative comparison of [18F]fallypride PET binding potential estimates using reference tissue models in rat brains. In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 [7582183] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2015.7582183