Quantitative comparison of [18F]fallypride PET binding potential estimates using reference tissue models in rat brains

Dianne E. Lee; Siva Muthusamy; Dima A. Hammoud

doi:10.1109/NSSMIC.2015.7582183

Quantitative comparison of [¹⁸F]fallypride PET binding potential estimates using reference tissue models in rat brains

Dianne E. Lee, Siva Muthusamy, Dima A. Hammoud

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The purpose of our study was to compare commonly used mathematical models for analyzing dynamic [¹⁸F]fallypride PET data in rat brains when arterial input function is not available. For the quantification of dopamine D_2/3 receptors, we compared the time activity curves (TACs) and binding potential estimates using several simplified methods, including the 1T simplified reference tissue model (SRTM), using 60 minutes versus 90 minutes of emission recording, the 2T Reference method, and the equilibrium concentration ratios. The reliability of fit of the tissue time activity curves (TACs) and the binding potential estimates were then compared.

Original language	English (US)
Title of host publication	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781467398626
DOIs	https://doi.org/10.1109/NSSMIC.2015.7582183
State	Published - Oct 3 2016
Event	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 - San Diego, United States Duration: Oct 31 2015 → Nov 7 2015

Publication series

Name	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015

Other

Other	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
Country/Territory	United States
City	San Diego
Period	10/31/15 → 11/7/15

ASJC Scopus subject areas

Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging
Instrumentation

Access to Document

10.1109/NSSMIC.2015.7582183

Cite this

Lee, D. E., Muthusamy, S., & Hammoud, D. A. (2016). Quantitative comparison of [¹⁸F]fallypride PET binding potential estimates using reference tissue models in rat brains. In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 Article 7582183 (2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2015.7582183

Quantitative comparison of [¹⁸F]fallypride PET binding potential estimates using reference tissue models in rat brains. / Lee, Dianne E.; Muthusamy, Siva; Hammoud, Dima A.
2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., 2016. 7582183 (2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lee, DE, Muthusamy, S & Hammoud, DA 2016, Quantitative comparison of [¹⁸F]fallypride PET binding potential estimates using reference tissue models in rat brains. in 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015., 7582183, 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, Institute of Electrical and Electronics Engineers Inc., 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, San Diego, United States, 10/31/15. https://doi.org/10.1109/NSSMIC.2015.7582183

Lee DE, Muthusamy S, Hammoud DA. Quantitative comparison of [¹⁸F]fallypride PET binding potential estimates using reference tissue models in rat brains. In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc. 2016. 7582183. (2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015). doi: 10.1109/NSSMIC.2015.7582183

Lee, Dianne E. ; Muthusamy, Siva ; Hammoud, Dima A. / Quantitative comparison of [¹⁸F]fallypride PET binding potential estimates using reference tissue models in rat brains. 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., 2016. (2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015).

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abstract = "The purpose of our study was to compare commonly used mathematical models for analyzing dynamic [18F]fallypride PET data in rat brains when arterial input function is not available. For the quantification of dopamine D2/3 receptors, we compared the time activity curves (TACs) and binding potential estimates using several simplified methods, including the 1T simplified reference tissue model (SRTM), using 60 minutes versus 90 minutes of emission recording, the 2T Reference method, and the equilibrium concentration ratios. The reliability of fit of the tissue time activity curves (TACs) and the binding potential estimates were then compared.",

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