@article{7e8b2cc4c4274b66b05f65dfcefb9c36,
title = "Quantitative carcinogenesis in man: Solar ultraviolet b dose dependence of skin cancer in Maryland Watermen",
abstract = "Skin cancer is the most common form of cancer in humans and occurs primarily on sun-exposed areas of the body. In a study of 808 Caucasian Maryland watermen, we examined the prevalence of nonmelanoma skin cancer in relation to age and exposure to solar ultraviolet B (UVB) radiation. For each study subject, the exposure to solar UVB radiation for each year of life after the age of 16 years was calculated. We obtained the data for this analysis by combining a detailed occupational history with laboratory and field measurements. Prevalence of the three major types of nonmelanoma skin neoplasms was analyzed: squa-mous cell carcinoma (SCC), basal cell carcinoma (BCC), and actinic kerato-sis (AK). Average annual exposure to UVB radiation was strongly correlated with the prevalence of SCC, but not with the prevalence of BCC or AK. This finding is consistent with dose saturation (plateau in dose-response relationship) for the induction of BCC and AK in humans with high annual exposure to UVB radiation. In addition, two small groups of apparently hypersus-ceptible individuals were present in the population. One group had SCC despite low annual exposure to UVB radiation, and the other group had multiple skin cancers despite average exposure to UVB radiation. [J Natl Cancer Inst 81: 1910-1913, 1989].",
author = "Strickland, {Paul T.} and Vitasa, {Benjamin C.} and West, {Sheila K.} and Rosenthal, {Frank S.} and Emmett, {Edward A.} and Taylor, {Hugh R.}",
note = "Funding Information: Received May 16, 1989; revised September 1, 1989; accepted September 6, 1989. Supported in part by Public Health Service grants EY-04547 (National Eye Institute), ES-03841 (National Institute of Environmental Health Sciences), and AR-38884 (National Institute of Arthritis and Musculoskeletal and Skin Diseases), National Institutes of Health, Department of Health and Human Services; and by the World Health Organization. P. T. Strickland, B. C. Vitasa, F. S. Rosen-thai, E. A. Emmett, Department of Environmental Health Sciences, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD. Present address E. A. Emmett, National Occupational Health and Safety Commission, G.P.O. Box 58, Sydney, New South Wales 2001, Australia. S. K. West, H. R. Taylor, Dana Center for Preventive Ophthalmology, The Wilmer Institute, The Johns Hopkins Medical Institutions, Baltimore, MD. We thank H. Newland, A. Bakalian, P. Prestia, S. Simons, C. Phoon, S. K. Ng, and C. Swift for assistance in the field; H. Abbey, B. Munoz, and K. Kolodner for assistance with data analysis; and members of the Maryland Watermen Association who participated in the study. 'Correspondence to: Dr. Paul T. Strickland, Department of Environmental Health Sciences, Rm. 2708, The Johns Hopkins School of Hygiene and Public Health, 615 N. Wolfe St., Baltimore, MD 21205. Funding Information: Supported by Public Health Service grant CA-44704 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. Copyright: Copyright 2010 Elsevier B.V., All rights reserved.",
year = "1989",
month = dec,
day = "20",
doi = "10.1093/jnci/81.24.1910",
language = "English (US)",
volume = "81",
pages = "1910--1913",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "24",
}