Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

Michael B. Knable, Thomas Hyde, Michael F. Egan, Mehmet Tosayali, Richard J. Wyatt, Joel Kleinman

Research output: Contribution to journalArticle

Abstract

Rats treated with haloperidol that developed vacuous chewing movements (VCM), a possible animal model of tardive dyskinesia, were studied with quantitative autoradiography for dopamine type-1 (D1) and type-2 (D2) receptors as well as dopamine re-uptake sites. Haloperidol increased striatal D2 receptors, but did not affect D1 receptors or the dopamine re-uptake site. D2 receptor increases occurred in rats with and without VCMs. In so far as VCM is a model for tardive dyskinesia, haloperidol induced increases in striatal D2 receptors do not appear to be etiologic for these abnormal movements.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalBrain Research
Volume646
Issue number2
DOIs
StatePublished - May 23 1994
Externally publishedYes

Fingerprint

Corpus Striatum
Mastication
Haloperidol
Autoradiography
Dopamine
Dyskinesias
Dopamine Receptors
Animal Models
Tardive Dyskinesia

Keywords

  • Autoradiography
  • Dopamine
  • Dopamine receptor
  • Neuroleptic
  • Tardive dyskinesia
  • Vacuous chewing movement

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements. / Knable, Michael B.; Hyde, Thomas; Egan, Michael F.; Tosayali, Mehmet; Wyatt, Richard J.; Kleinman, Joel.

In: Brain Research, Vol. 646, No. 2, 23.05.1994, p. 217-222.

Research output: Contribution to journalArticle

Knable, Michael B. ; Hyde, Thomas ; Egan, Michael F. ; Tosayali, Mehmet ; Wyatt, Richard J. ; Kleinman, Joel. / Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements. In: Brain Research. 1994 ; Vol. 646, No. 2. pp. 217-222.
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