Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

Michael B. Knable, Thomas M. Hyde, Michael F. Egan, Mehmet Tosayali, Richard J. Wyatt, Joel E. Kleinman

Research output: Contribution to journalArticlepeer-review

Abstract

Rats treated with haloperidol that developed vacuous chewing movements (VCM), a possible animal model of tardive dyskinesia, were studied with quantitative autoradiography for dopamine type-1 (D1) and type-2 (D2) receptors as well as dopamine re-uptake sites. Haloperidol increased striatal D2 receptors, but did not affect D1 receptors or the dopamine re-uptake site. D2 receptor increases occurred in rats with and without VCMs. In so far as VCM is a model for tardive dyskinesia, haloperidol induced increases in striatal D2 receptors do not appear to be etiologic for these abnormal movements.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalBrain research
Volume646
Issue number2
DOIs
StatePublished - May 23 1994
Externally publishedYes

Keywords

  • Autoradiography
  • Dopamine
  • Dopamine receptor
  • Neuroleptic
  • Tardive dyskinesia
  • Vacuous chewing movement

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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