Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

Michael B. Knable; Thomas M. Hyde; Michael F. Egan; Mehmet Tosayali; Richard J. Wyatt; Joel E. Kleinman

doi:10.1016/0006-8993(94)90081-7

Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

Michael B. Knable, Thomas M. Hyde, Michael F. Egan, Mehmet Tosayali, Richard J. Wyatt, Joel E. Kleinman

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Rats treated with haloperidol that developed vacuous chewing movements (VCM), a possible animal model of tardive dyskinesia, were studied with quantitative autoradiography for dopamine type-1 (D1) and type-2 (D2) receptors as well as dopamine re-uptake sites. Haloperidol increased striatal D2 receptors, but did not affect D1 receptors or the dopamine re-uptake site. D2 receptor increases occurred in rats with and without VCMs. In so far as VCM is a model for tardive dyskinesia, haloperidol induced increases in striatal D2 receptors do not appear to be etiologic for these abnormal movements.

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Brain research
Volume	646
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)90081-7
State	Published - May 23 1994
Externally published	Yes

Keywords

Autoradiography
Dopamine
Dopamine receptor
Neuroleptic
Tardive dyskinesia
Vacuous chewing movement

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(94)90081-7

Cite this

@article{a7662032fbb54c6285796b35d66f6033,

title = "Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements",

abstract = "Rats treated with haloperidol that developed vacuous chewing movements (VCM), a possible animal model of tardive dyskinesia, were studied with quantitative autoradiography for dopamine type-1 (D1) and type-2 (D2) receptors as well as dopamine re-uptake sites. Haloperidol increased striatal D2 receptors, but did not affect D1 receptors or the dopamine re-uptake site. D2 receptor increases occurred in rats with and without VCMs. In so far as VCM is a model for tardive dyskinesia, haloperidol induced increases in striatal D2 receptors do not appear to be etiologic for these abnormal movements.",

keywords = "Autoradiography, Dopamine, Dopamine receptor, Neuroleptic, Tardive dyskinesia, Vacuous chewing movement",

author = "Knable, {Michael B.} and Hyde, {Thomas M.} and Egan, {Michael F.} and Mehmet Tosayali and Wyatt, {Richard J.} and Kleinman, {Joel E.}",

year = "1994",

month = may,

day = "23",

doi = "10.1016/0006-8993(94)90081-7",

language = "English (US)",

volume = "646",

pages = "217--222",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

AU - Knable, Michael B.

AU - Hyde, Thomas M.

AU - Egan, Michael F.

AU - Tosayali, Mehmet

AU - Wyatt, Richard J.

AU - Kleinman, Joel E.

PY - 1994/5/23

Y1 - 1994/5/23

N2 - Rats treated with haloperidol that developed vacuous chewing movements (VCM), a possible animal model of tardive dyskinesia, were studied with quantitative autoradiography for dopamine type-1 (D1) and type-2 (D2) receptors as well as dopamine re-uptake sites. Haloperidol increased striatal D2 receptors, but did not affect D1 receptors or the dopamine re-uptake site. D2 receptor increases occurred in rats with and without VCMs. In so far as VCM is a model for tardive dyskinesia, haloperidol induced increases in striatal D2 receptors do not appear to be etiologic for these abnormal movements.

AB - Rats treated with haloperidol that developed vacuous chewing movements (VCM), a possible animal model of tardive dyskinesia, were studied with quantitative autoradiography for dopamine type-1 (D1) and type-2 (D2) receptors as well as dopamine re-uptake sites. Haloperidol increased striatal D2 receptors, but did not affect D1 receptors or the dopamine re-uptake site. D2 receptor increases occurred in rats with and without VCMs. In so far as VCM is a model for tardive dyskinesia, haloperidol induced increases in striatal D2 receptors do not appear to be etiologic for these abnormal movements.

KW - Autoradiography

KW - Dopamine

KW - Dopamine receptor

KW - Neuroleptic

KW - Tardive dyskinesia

KW - Vacuous chewing movement

UR - http://www.scopus.com/inward/record.url?scp=0028270950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028270950&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(94)90081-7

DO - 10.1016/0006-8993(94)90081-7

M3 - Article

C2 - 8069667

AN - SCOPUS:0028270950

SN - 0006-8993

VL - 646

SP - 217

EP - 222

JO - Brain research

JF - Brain research

IS - 2

ER -

Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this