Quantitative autoradiographic localization of D-1 dopamine receptors in the rat brain: Use of the iodinated ligand [125I]SCH 23982

Ted M. Dawson, Paolo Barone, Anita Sidhu, James K. Wamsley, Thomas N. Chase

Research output: Contribution to journalArticle

Abstract

In vitro autoradiography was used to visualize [125I]SCH 23982 binding sites in rat brain. Labeling was concentrated in the caudate-putamen, accumbens nucleus, olfactory tubercle, substantia nigra pars reticulata and the entopeduncular nucleus. [125I]SCH 23982 labels predominantly D-1 receptors but also labels 5-HT2 receptors in certain areas of the brain. These findings may relate to the distribution of dopamine's cerebral loci of action on D-1 receptors.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalNeuroscience Letters
Volume68
Issue number3
DOIs
StatePublished - Aug 4 1986
Externally publishedYes

Keywords

  • [I]SCH 23982
  • autoradiography
  • dopamine D-1 receptor
  • receptor binding

ASJC Scopus subject areas

  • Neuroscience(all)

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