Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI

Peiying Liu, Hao Huang, Nancy Rollins, Lina F. Chalak, Tina Jeon, Cathy Halovanic, Hanzhang Lu

Research output: Contribution to journalArticle

Abstract

The cerebral metabolic rate of oxygen (CMRO2) is the rate of oxygen consumption by the brain, and is thought to be a direct index of energy homeostasis and brain health. However, in vivo measurement of CMRO2 is challenging, in particular for the neonatal population, in whom conventional radiotracer methods are not applicable because of safety concerns. In this study, we propose a method to quantify global CMRO2 in neonates based on arteriovenous differences in oxygen content, and employ separate measurements of oxygenation and cerebral blood flow (CBF) parameters. Specifically, arterial and venous oxygenation levels were determined with pulse oximetry and the novel T2 relaxation under spin tagging (TRUST) MRI, respectively. Global CBF was measured with phase contrast (PC) flow velocity MRI. The proposed method was implemented on a standard 3-T MRI scanner without the need for any exogenous tracers, and the total scan duration was less than 5min. We demonstrated the feasibility of this method in 12 healthy neonates within an age range of 35-42 gestational weeks. CMRO2 values were successfully obtained from 10 neonates. It was found that the average CMRO2 in this age range was 38.3±17.7μmol/100g/min and was positively correlated with age (p=0.007; slope, 5.2μmol/100g/min per week), although the highest CMRO2 value in this age range was still less than half of the adult level. Test-retest studies showed a coefficient of variation of 5.8±2.2% between repeated CMRO2 measurements. In addition, given the highly variable blood flow velocity within this age range, it is recommended that the TRUST labeling thickness and position should be determined on a subject-by-subject basis, and an automatic algorithm was developed for this purpose. Although this method provides a global CMRO2 measure only, the clinical significance of an energy consumption marker and the convenience of this technique may make it a useful tool in the functional assessment of the neonatal population.

Original languageEnglish (US)
Pages (from-to)332-340
Number of pages9
JournalNMR in Biomedicine
Volume27
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

Fingerprint

Magnetic resonance imaging
Blood
Oxygenation
Oxygen
Cerebrovascular Circulation
Flow velocity
Brain
Functional assessment
Labeling
Energy utilization
Health
Oximetry
Blood Flow Velocity
Oxygen Consumption
Population
Homeostasis
Safety

Keywords

  • Baby
  • Brain
  • CMRO
  • Energy consumption
  • Fetus
  • TRUST

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI. / Liu, Peiying; Huang, Hao; Rollins, Nancy; Chalak, Lina F.; Jeon, Tina; Halovanic, Cathy; Lu, Hanzhang.

In: NMR in Biomedicine, Vol. 27, No. 3, 03.2014, p. 332-340.

Research output: Contribution to journalArticle

Liu, Peiying ; Huang, Hao ; Rollins, Nancy ; Chalak, Lina F. ; Jeon, Tina ; Halovanic, Cathy ; Lu, Hanzhang. / Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI. In: NMR in Biomedicine. 2014 ; Vol. 27, No. 3. pp. 332-340.
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