TY - GEN
T1 - Quantitative assessment of Diabetic Macular Edema using fluorescein leakage maps
AU - Magdy, Eman
AU - Agbedia, Owhofasa O.
AU - Ibrahim, Mohamed
AU - Nguyen, Quan D.
AU - Fahmy, Ahmed S.
PY - 2012
Y1 - 2012
N2 - Diagnosis of Diabetic Macular Edema (DME) from Fundus Fluorescein Angiography (FFA) image sequences is a standard clinical practice. Nevertheless, current methods depend on subjective evaluation of the amount of fluorescein leakage in the images which lack reproducibility and require well-trained grader. In this work, we present a method for processing FFA images to generate a fluorescein leakage map that can be used for quantitative evaluation of DME. An essential step in the proposed method is to model the spatial distribution of the image intensity within the macula. This model, which represents the non-leaking structures, is then subtracted from the late timeframe image to enhance the areas of fluorescein leakage. The resulting difference image is then mapped with empirical linear transformation to produce a color Fluorescein Leakage Map (FLM) that can be used for quantitative assessment and detection of DME. The method was applied to 13 image sequences for 13 different patients. The resulting FLM maps were found to be correlated with the thickness maps produced by Optical Coherence Tomography (OCT). The relatively high correlation between the FLM and OCT maps show the potential and of using the developed method for quantitatively assess the DME in FFA image sequences.
AB - Diagnosis of Diabetic Macular Edema (DME) from Fundus Fluorescein Angiography (FFA) image sequences is a standard clinical practice. Nevertheless, current methods depend on subjective evaluation of the amount of fluorescein leakage in the images which lack reproducibility and require well-trained grader. In this work, we present a method for processing FFA images to generate a fluorescein leakage map that can be used for quantitative evaluation of DME. An essential step in the proposed method is to model the spatial distribution of the image intensity within the macula. This model, which represents the non-leaking structures, is then subtracted from the late timeframe image to enhance the areas of fluorescein leakage. The resulting difference image is then mapped with empirical linear transformation to produce a color Fluorescein Leakage Map (FLM) that can be used for quantitative assessment and detection of DME. The method was applied to 13 image sequences for 13 different patients. The resulting FLM maps were found to be correlated with the thickness maps produced by Optical Coherence Tomography (OCT). The relatively high correlation between the FLM and OCT maps show the potential and of using the developed method for quantitatively assess the DME in FFA image sequences.
KW - Diabetic Macular Edema
KW - Digital Subtraction
KW - Fluorescein Angiography
KW - Optical Coherence Tomography
UR - http://www.scopus.com/inward/record.url?scp=84875824971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875824971&partnerID=8YFLogxK
U2 - 10.1109/ICIP.2012.6467489
DO - 10.1109/ICIP.2012.6467489
M3 - Conference contribution
AN - SCOPUS:84875824971
SN - 9781467325332
T3 - Proceedings - International Conference on Image Processing, ICIP
SP - 2833
EP - 2836
BT - 2012 IEEE International Conference on Image Processing, ICIP 2012 - Proceedings
T2 - 2012 19th IEEE International Conference on Image Processing, ICIP 2012
Y2 - 30 September 2012 through 3 October 2012
ER -