Quantitative assessment of changes in trabeculectomy blebs after laser suture lysis using anterior segment coherence tomography

Chelvin C.A. Sng, Mandeep Singh, Paul Tec Kuan Chew, Cheryl S. Ngo, Ce Zheng, Tin A. Tun, Jovina L.S. See, Marcus Ang, Seng Chee Loon, Tin Aung

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To quantify changes in bleb morphology after laser suture lysis (LSL) using anterior segment optical coherence tomography (AS-OCT). PATIENTS AND METHODS: This was a prospective observational case series of patients who underwent trabeculectomy surgery with mitomycin-C and required subsequent LSL. Subjects were assessed before and immediately after LSL, and at 3 months after LSL. At each visit, a standardized cross-sectional AS-OCT image of the bleb was obtained, from which a masked observer measured bleb height (hB), cavity height (hC), wall cross sectional area (AW), cavity cross sectional area (AC), and bleb cross sectional area (AB) using custom software. RESULTS: Twenty-five subjects (25 eyes) were examined. LSL was performed at a mean of 21.5±16.3 days after trabeculectomy. Immediately after LSL, there was a significant increase in mean hB (P=0.026) and mean hC (P=0.45) from pre-LSL. At 3 months after LSL, there was a significant increase in mean hB (P=0.003), mean AC (P=0.047), and mean AB (P=0.006) as compared with before LSL. Increase in hB and hC immediately after LSL was predictive of outcome at month 3. CONCLUSIONS: AS-OCT was able to quantify changes in bleb morphology after LSL, some of which were predictive of eventual outcome.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalJournal of glaucoma
Volume21
Issue number5
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • anterior segment
  • imaging systems
  • trabeculectomy

ASJC Scopus subject areas

  • Ophthalmology

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